Modern techniques offer an opportunity for a more complete evaluation of melanin
production in the uvea and retinal pigment epithelium (RPE). By measuring the release of …

Tyrosinase (EC 1.14. 18.1) is the rate limiting enzyme of melanogenesis and it is unclear
whether it is synthesized in postnatal retinal pigment epithelium (RPE). Cultured RPE cells …

Complementary DNA clones coding for chicken tyrosinase were isolated from retinal
pigmented epithelium of chicken embryo. Sequence analysis shows that one of the cDNA …

To study the relationship among tyrosinase activity, melanin production, and the routing of
retinal ganglion cell (RGC) axons at the optic chiasm, we analysed mice with varying doses …

According to recent theory on the structure of melanin, the sulfur content of melanin is a
reflection of the amount of cysteine used in its manufacture. We compared the sulfur …

This paper is a review of what is known about the turnover of melanin in iris, choroid, and
retinal pigment epithelium (RPE) of the adult vertebrate eye. Differences in size and …

Abstract Background Tyrosinase (EC 1.14. 18.1) is the key enzyme of melanin pigment
formation and it is unclear whether it is synthesized in human postnatal retinal pigment …

PURPOSE: To study melanogenesis by cultured human uveal melanocytes, and the
relationship between melanin production by uveal melanocytes in vitro with the degree of …

Whether melanogenesis occurs in adult eyes is still a matter of controversy. It has been
widely held that the pigment epithelial cells are fully melanized at birth, and that the uveal …

Melanin concentrations were analyzed in the pigment epithelium of 61 postmortem normal
human eyes from donors 14-97 yr of age. The content of soluble melanin in the pigment …