Bone remodeling is accompanied by the differentiation of osteoclasts from the monocyte/
macrophage lineage of hematopoietic cells. The osteoclast differentiation process requires …

Recent studies have revealed the essential role of the receptor activator of nuclear factor κB
(NF‐κB) ligand (RANKL) in osteoclast differentiation and activation. Adenovirus vector could …

The role of the receptor activator of nuclear factor κB (NF‐κB) ligand (RANKL)—a tumor
necrosis factor (TNF)‐related cytokine—in osteoclast formation has been established …

Receptor activator of NF-κB ligand (RANKL) and its receptor activator of NF-κB (RANK) play
pivotal roles in osteoclast differentiation and function. However, the structural determinants …

Chemokines play an important role in immune and inflammatory responses by inducing
migration and adhesion of leukocytes, and have also been reported to modulate osteoclast …

Phosphatidylinositol 3-kinase (PI 3-kinase) and mitogen-activated protein kinases (MAPKs)
have been implicated in diverse cellular functions, including proliferation, migration, and …

While TNF-α is pivotal to the pathogenesis of inflammatory osteolysis, the means by which it
recruits osteoclasts and promotes bone destruction are unknown. We find that a pure …

Osteoclasts are multinucleated cells that differentiate from hematopoietic cells and possess
characteristics responsible for bone resorption. To study the involvement of mitogen …

NF-κB is a pleiotropic transcription factor, which regulates osteoclast formation, function, and
survival. The finding that the deletion of both NF-κB p50 and p52 subunits resulted in …

The transcription factor NF-κB is a family of proteins involved in signaling pathways essential
for normal cellular functions and development. Deletion of various components of this …