Dendrimers - reflections on host-guest interaction mechanism towards solubility enhancement
Page 1 188 Asian Journal of Pharmaceutics - July-September 2009 INTRODUCTION In the …

Poor solubility and hydrophobicity of drugs/bioactives limit their possible applications in drug
delivery and formulation development. Apart from conventional methods of solubility …

A drug is effective in their molecular form; thus solubility in the biological fluid is important.
Pharmaceutical researchers are continuously working on the improvement of solubility of …

High solubility, high permeability and good stability are basic prerequisites for achieving the
bioavailability and hence therapeutic effectiveness. Newly developed drugs having poor …

Dendrimers are 3D, hyperbranched, tree-like polymers having immense potential in drug
delivery, targeting, diagnosis and as carriers for DNA/gene delivery. Dendrimers have …

Sufficient fluid solvency has been one in everything about required properties while
choosing drug particles and completely uncommon bio-actives for advancement. Here and …

Adequate aqueous solubility has been one of the desired properties while selecting drug
molecules and other bio-actives for product development. Often solubility of a drug …

Dendrimers today are known for their three dimensional, monodispersed, highly branched,
macromolecular nano-scopic architecture with number of reactive end groups. Dendrimers …

Understanding the dendrimer–drug interaction is of great importance to design and optimize
the dendrimer-based drug delivery system. Using atomistic molecular dynamics (MD) …

Editorial periphery, which forms a closed membrane-like structure [3]. When a critical stage
is reached dendrimers cannot grow because of steric hindrance. This is sometimes referred …