One of the most powerful strategies to investigate biology we have as scientists, is the ability
to transfer genetic material in a controlled and deliberate manner between organisms. When …

Since the initial demonstration in 1982 of profound phenotypic effects stemming from the
expression of a single transgene, genetic engineering has revolutionized fundamental …

The domestic pig is an ideal “dual purpose” animal model for agricultural and biomedical
research. With the availability of genome editing tools such as clustered regularly …

Due to recent innovations in gene editing technology, great progress has been made in
livestock breeding, with researchers rearing gene-edited pigs, cattle, sheep, and other …

Transgenic technologies used for creating a desired genomic change in animals involve
three critical steps: isolation of fertilized eggs, microinjection of transgenic DNA into them …

The use of CRISPR-Cas and RNA-guided endonucleases has drastically changed research
strategies for understanding and exploiting gene function, particularly for the generation of …

Large animals (non-human primates, livestock and dogs) are playing important roles in
biomedical research, and large livestock animals serve as important sources of meat and …

The major goal of animal breeding is the genetic enhancement of economic traits. The
CRISPR/Cas system, which includes nuclease-mediated and base editor mediated genome …

The introduction of genome editing reagents into mammalian zygotes has traditionally been
accomplished by cytoplasmic or pronuclear microinjection. This time-consuming procedure …

Genetic modification of livestock has a longstanding and successful history, starting with
domestication several thousand years ago. Modern animal breeding strategies …