The generation of genetically modified animals is important for both research and
commercial purposes. The rat is an important model organism that until recently lacked …

Transgenic animals are important components of modern biomedical and veterinary
sciences. They produce recombinant proteins, enzymes and antibodies for treating diseases …

The beginning of this century has witnessed great advances in the understanding of ovarian
physiology and embryo development, in the improvement of assisted reproductive …

Precise genome editing of large animals applied to livestock and biomedicine is nowadays
possible since the CRISPR revolution. This review summarizes the latest advances and the …

Background Genome editing has been considered as powerful tool in agricultural fields.
However, genome editing progress in cattle has not been fast as in other mammal species …

Genome editing in pigs has tremendous practical applications for biomedicine. The advent
of genome editing technology, with its use of site‐specific nucleases—including ZFNs …

Abstract Genome/gene-editing (GE) techniques, characterized by a low technological
barrier, high efficiency, and broad application among organisms, are now being employed …

Abstract Background: The porcine species (Sus scrofa domesticus) has had a great impact
as a source of food worldwide, but also it is a very useful animal for biomedical applications …

Genetically modified pigs have been considered favorable resources in xenotransplantation.
Microinjection of randomly integrating transgenes into zygotes, somatic cell nuclear transfer …

Pigs have anatomical, physiological and genomic characteristics that make them highly
suitable for modeling human diseases. Genetically modified (GM) pig models of human …