Despite the classical peripheral pronociceptive effect of noradrenaline (NA), recently studies
showed the involvement of NA in antinociceptive effect under immune system interaction. In …

The involvement of nitric oxide (NO), cyclic GMP and ATP-sensitive K+ channels in the
antinociceptive effect of ketorolac was assessed using the formalin test in the rat. Local …

BACKGROUND: The involvement of the l-arginine/nitric oxide (NO)/cyclic guanosine
monophosphate (cGMP) pathway in antinociception has been implicated as a molecular …

Pamabrom is a diuretic that is effective in treating premenstrual syndrome and primary
dysmenorrhea. The aim of this study was to examine the effect of metformin and modulators …

Background The aim of this study was to investigate this involvement in not inflammatory
model of pain and which opioid receptor subtype mediates noradrenaline-induced …

Abstract Angiotensin-(1–7) is a bioactive component of the renin–angiotensin system that is
formed endogenously and induces nitric oxide release in several tissues. The l …

The aim of this study was to examine if the peripheral antinociceptive effects of the opioid
agonist/antagonist nalbuphine and buprenorphine involve the sequential participation of …

The l-arginine/nitric oxide/cyclic GMP pathway has been proposed as the mechanism of
action for peripheral antinociception concerning several groups of drugs, including opioids …

Using the rat paw pressure test, in which sensitivity is increased by intraplantar injection of
prostaglandin E2 (PGE2), we conducted a study using several K+ channel blockers. The …

In order to investigate to the contribution of K+ channels on the peripheral antinociception
induced by diclofenac, we evaluated the effect of several K+ channel blockers, using the rat …