Recent investigations and discussions have emphasized not whether tyrosine was a
precursor in melanin formation as had been the controversy for over fifty years (Fitzpatrick …

Tyrosinase activity was assayed in black and white human foreskin samples by measuring
both the hydroxylation of tyrosine to dopa (tyrosine hydroxylase activity) and the conversion …

This work describes a comparative study of the tyrosinase activity determined using three
methods which are the most extensively employed; two radiometric assays using L‐tyrosine …

Raper 1 and his associates, in a comprehensive study of the tyrosine-tyrosinase reaction,
showed that the enzyme tyrosinase obtained from plant sources catalyzes the conversion of …

Introduction It is generally assumed that tyrosine is the precursor of melanin formed in
human skin (Lerner and Fitzpatrick, 1950). The specific enzyme for melanogenesis …

RESEARCH on the biochemistry of melanogenesis can be divided historically into three
periods. 1 1. The identification of tryosinase, in 1895, by Bertrand and Bourquelot in certain …

THE INCREASE in pigmentation accompanying atrophy or tuberculosisof the adrenal cortex
has been an established clinical fact sinceAddison2s (1885) original description of the …

Tyrosinase activity (Monophenol, dihydroxyphenylalanine: oxygen oxidoreductase EC 1.14.
18.1) in vitiligo and normal epidermal homogenates of skin from human beings was …

The enzyme tyrosinase, which catalyzes the aerobic oxidation of tyrosine to produce the
pigment melanin, is found widely distributed in nature. Much has been reported (1, 2) on …

Raper (1) and his associates showed in a comprehensive study of the tyrosine-tyrosinase
reaction that the enzyme tyrosinase obtained from plant sources catalyzes the conversion of …