Purpose: Topoisomerase inhibitors including camptothecin are being studied as potential
radiosensitizers. CPT-11 is a derivative of camptothecin and is clinically available. In this …

Abstract Knowledge of the type of biological reaction to chemotherapy is a prerequisite for its
rational enhancement. We previously showed that irinotecan-induced DNA damage triggers …

Abstract Mack, PC, Jones, AA, Gustafsson, MH, Gandara, DR, Gumerlock, PH and Goldberg,
Z. Enhancement of Radiation Cytotoxicity by UCN-01 in Non-small Cell Lung Carcinoma …

SN 28049 is a novel DNA intercalating anti-cancer drug developed at the Auckland Cancer
Society Research Centre as part of ongoing research into topoisomerase II poisons with …

Our goal was to determine the cytotoxicity of 7-OH-hydroxystaurosporine (UCN-01) as a
single agent and in combination with cis-diamminedichloroplatinum (II)(CDDP) in a panel of …

We have previously shown that p53 disruption sensitizes certain cancer cell types to
cisplatin (CDDP)(Fan et al., 1995). In the present study we investigated the role of the p53 …

Camptothecin (CPT) traps covalent DNA topoisomerase I-linked DNA single-strand breaks
(cleavable complexes). To determine the differences in DNA damage signalling leading to …

HL-60 cells that stably express transfected wild-type (wt) p53 were used to determine
whether restoration of wt p53 increased the chemosensitivity of cells that normally lack p53 …

The tumor suppressor p53 has been implicated in apoptosis induction and is mutated in
human T-ALL CCRF-CEM cells. To investigate possible consequences of wild-type p53 …

The combination of the microtubule active drug taxol with radiation has shown promise for
use in combined modality therapy. Recent studies have demonstrated that radiation and a …