Background—The progression of atrial fibrillation (AF) from paroxysmal to persistent forms
remains a major clinical challenge. Abnormal sarcoplasmic reticulum (SR) Ca2+ leak via the …

DR Van Wagoner and JM Nerbonne. Molecular Basis of Electrical Remodeling in Atrial
Fibrillation. Journal of Molecular and Cellular Cardiology (2000) 32, 1101–1117. Atrial …

The complexity of the heart makes an intuitive understanding of the relative contribution of
ion channels, transporters and signalling pathways to cardiac electrophysiology …

The mechanisms to explain atrial fibrillation (AF) have been widely debated. Although
contemporary experimental techniques have provided more insight, hypotheses regarding …

Aims β-adrenergic stimulation has profound influence in the genesis and maintenance of
atrial fibrillation (AF). However, the effects of β-Adrenoceptor stimulation on repolarizing …

Background—Transient atrial contractile dysfunction (“atrial stunning”) follows conversion of
atrial fibrillation (AF) to sinus rhythm and has significant clinical implications; however, the …

One of the most exciting developments in our understanding of atrial fibrillation (AF) over the
last several years has been the recognition that AF itself modifies atrial electrical properties …

Atrial fibrillation (AF) affects more than three million people per year in the United States and
is associated with high morbidity and mortality. Both electrical and structural remodeling …

Atrial fibrillation (AF) is the most common sustained arrhythmia encountered in clinical
practice, yet our understanding of the mechanisms that initiate and sustain this arrhythmia …