Adaptation of the brain to the presence of a drug predicts withdrawal on cessation. The
outcome of adaptation is often referred to as 'physical dependence'in pharmacology, as …

We read with great interest the recent review of antidepressant withdrawal by Davies and
Read and the widespread press coverage which followed. We agree that symptoms …

Introduction The UK's current National Institute for Health and Care Excellence and the
American Psychiatric Association's depression guidelines state that withdrawal reactions …

Withdrawal reactions when coming off antidepressants have long been neglected or
minimised. It took almost two decades after the selective serotonin reuptake inhibitors …

Background While case reports and clinical trials reported withdrawal syndrome after
reduction and/or discontinuation of antidepressant drugs, no large study has been …

We now recognise that withdrawal symptoms from antidepressants are common, and can be
severe and long-lasting in some people. Many withdrawal symptoms overlap with symptoms …

A substantial proportion of the burden of depression arises from its recurrent nature. The risk
of relapse after antidepressant medication (ADM) discontinuation is high but not uniform …

Introduction The incidence and severity of withdrawal effects when coming off
antidepressants (ADs) have recently received considerable attention. National guidelines on …

Introduction Evidence is lacking on withdrawal syndrome related to individual
antidepressants and relevant risk factors for severe reactions. Objective To ascertain …

Controversy continues with regard to antidepressants and withdrawal. Recent debates have
focused on the prevalence and length of withdrawal, and some continue to state that …