1 The pharmacological profile of GR94839, a κ‐opioid agonist with limited access to the
central nervous system, has been investigated. Its antinociceptive activity has been …

1 CI‐977 is a new, nonpeptide κ‐opioid compound that has been synthesized and its
pharmacological properties determined in a series of in vitro and in vivo rodent models. 2 In …

1 The pharmacological characteristics of the κ‐opioid receptor agonist, EMD 60400, have
been investigated, with particular reference to its central and peripheral sites of action and …

1 Nociceptive thresholds to noxious mechanical (paw pressure) and thermal (tail flick)
stimuli were recorded in conscious rats. The effects of three selective κ‐opioid receptor …

We have already reported that TRK-820,(−)-17-cyclopropylmethyl-3, 14b-dihydroxy-4, 5a-
epoxy-6b-[N-methyl-trans-3-(3-furyl) acrylamido] morphinan hydrochloride, a new selective κ …

1 A new nonpeptide κ‐opioid compound, a cyclohexyl benzeneacetamide derivative
(PD117302), has been synthesized and its affinity for the different types of opioid receptor …

Abstract 1 PD 117302, a new nonpeptide opioid compound shown in in vitro studies to be a
selective kappa-opioid agonist, has been evaluated in vivo for antinociceptive activity and …

1 The pharmacological properties of the novel diarylacetamide k‐opioid receptor agonist,
EMD 61753, have been compared with those of ICI 197067 (a centrally‐acting k agonist) …

1 Release of substance P in the dorsal horn is considered a primary event in the perception
of pain. The profile of racemic RP67580, a non‐peptide antagonist at the NK1 (substance P) …

Agonists at K-opioid receptors may preserve the analgesic properties of [mu]-opioidergic
agonists while avoiding their major adverse effects. The present study was aimed to …