Activation of peripheral ATP-sensitive K+ channels mediates the antinociceptive effect of Crotalus durissus terrificus snake venom

G Picolo, AC Cassola, Y Cury - European journal of pharmacology, 2003 - Elsevier
The role of peripheral potassium channels on the antinociceptive effect of Crotalus durissus
terrificus venom, a mixed δ-and κ-opioid receptor agonist, was investigated in hyperalgesia …

δ-Opioid receptors and nitric oxide mediate the analgesic effect of Crotalus durissus terrificus snake venom

G Picolo, R Giorgi, Y Cury - European journal of pharmacology, 2000 - Elsevier
The antinociceptive effect of Crotalus durissus terrificus venom was investigated in a model
of inflammatory hyperalgesia induced by carrageenin. The rat paw pressure test was …

Peripheral neuronal nitric oxide synthase activity mediates the antinociceptive effect of Crotalus durissus terrificus snake venom, a δ-and κ-opioid receptor agonist

G Picolo, Y Cury - Life sciences, 2004 - Elsevier
Previous work has shown that nitric oxide (NO) mediates the antinociceptive effect of
Crotalus durissus terrificus venom on carrageenin-induced hyperalgesia. In the present …

Tolerance to the antinociceptive effect of Crotalus durissus terrificus snake venom in mice is mediated by pharmacodynamic mechanisms

P Brigatte, FA Hoffmann, MM Bernardi, R Giorgi… - Toxicon, 2001 - Elsevier
Crotalus durissus terrificus venom exerts central and peripheral antinociceptive effect
mediated by opioid receptors. The present work investigated the tolerance to the …

The peripheral antinociceptive effect induced by morphine is associated with ATP‐sensitive K+ channels

ARA Rodrigues, IDG Duarte - British journal of pharmacology, 2000 - Wiley Online Library
The effect of several K+ channel blockers such as glibenclamide, tolbutamide,
charybdotoxin (ChTX), apamin, tetraethylammonium (TEA), 4‐aminopyridine (4‐AP) and …

The peripheral L-arginine–nitric oxide–cyclic GMP pathway and ATP-sensitive K+ channels are involved in the antinociceptive effect of crotalphine on neuropathic …

VP Gutierrez, VO Zambelli, G Picolo… - Behavioural …, 2012 - journals.lww.com
Crotalphine, a 14 amino acid peptide first isolated from the venom of the South American
rattlesnake Crotalus durissus terrificus, induces a peripheral long-lasting and opioid …

Crotalphine, a novel potent analgesic peptide from the venom of the South American rattlesnake Crotalus durissus terrificus

K Konno, G Picolo, VP Gutierrez, P Brigatte… - Peptides, 2008 - Elsevier
We have shown that the venom of the South American rattlesnake Crotalus durissus
terrificus induces a long-lasting antinociceptive effect mediated by activation of κ-and δ …

Involvement of ATP-sensitive K+ channels in the peripheral antinociceptive effect induced by dipyrone

DP Alves, IDG Duarte - European journal of pharmacology, 2002 - Elsevier
We evaluated the effect of several K+ channel blockers on the peripheral antinociception
induced by dipyrone using the rat paw pressure test, in which sensitivity is increased by …

ATP-gated K+ channel openers enhance opioid antinociception: indirect evidence for the release of endogenous opioid peptides

AB Lohmann, SP Welch - European journal of pharmacology, 1999 - Elsevier
The ATP-gated K+ channel openers—diazoxide, levcromakalim and morphine—enhance
K+ efflux by opening ATP-gated K+ channels, thereby inducing cell hyperpolarization …

Involvement of ATP‐sensitive K+ channels in the peripheral antinociceptive effect induced by ketamine

TRL Romero, IDG Duarte - Veterinary anaesthesia and analgesia, 2013 - Elsevier
Objective To investigate the contribution of K+ channels on peripheral antinociception
induced by ketamine. Study design Prospective experimental study. Animals 110 male …