Activation of peripheral ATP-sensitive K+ channels mediates the antinociceptive effect of Crotalus durissus terrificus snake venom
G Picolo, AC Cassola, Y Cury - European journal of pharmacology, 2003 - Elsevier
The role of peripheral potassium channels on the antinociceptive effect of Crotalus durissus
terrificus venom, a mixed δ-and κ-opioid receptor agonist, was investigated in hyperalgesia …
terrificus venom, a mixed δ-and κ-opioid receptor agonist, was investigated in hyperalgesia …
δ-Opioid receptors and nitric oxide mediate the analgesic effect of Crotalus durissus terrificus snake venom
G Picolo, R Giorgi, Y Cury - European journal of pharmacology, 2000 - Elsevier
The antinociceptive effect of Crotalus durissus terrificus venom was investigated in a model
of inflammatory hyperalgesia induced by carrageenin. The rat paw pressure test was …
of inflammatory hyperalgesia induced by carrageenin. The rat paw pressure test was …
Peripheral neuronal nitric oxide synthase activity mediates the antinociceptive effect of Crotalus durissus terrificus snake venom, a δ-and κ-opioid receptor agonist
G Picolo, Y Cury - Life sciences, 2004 - Elsevier
Previous work has shown that nitric oxide (NO) mediates the antinociceptive effect of
Crotalus durissus terrificus venom on carrageenin-induced hyperalgesia. In the present …
Crotalus durissus terrificus venom on carrageenin-induced hyperalgesia. In the present …
Tolerance to the antinociceptive effect of Crotalus durissus terrificus snake venom in mice is mediated by pharmacodynamic mechanisms
Crotalus durissus terrificus venom exerts central and peripheral antinociceptive effect
mediated by opioid receptors. The present work investigated the tolerance to the …
mediated by opioid receptors. The present work investigated the tolerance to the …
The peripheral antinociceptive effect induced by morphine is associated with ATP‐sensitive K+ channels
ARA Rodrigues, IDG Duarte - British journal of pharmacology, 2000 - Wiley Online Library
The effect of several K+ channel blockers such as glibenclamide, tolbutamide,
charybdotoxin (ChTX), apamin, tetraethylammonium (TEA), 4‐aminopyridine (4‐AP) and …
charybdotoxin (ChTX), apamin, tetraethylammonium (TEA), 4‐aminopyridine (4‐AP) and …
The peripheral L-arginine–nitric oxide–cyclic GMP pathway and ATP-sensitive K+ channels are involved in the antinociceptive effect of crotalphine on neuropathic …
VP Gutierrez, VO Zambelli, G Picolo… - Behavioural …, 2012 - journals.lww.com
Crotalphine, a 14 amino acid peptide first isolated from the venom of the South American
rattlesnake Crotalus durissus terrificus, induces a peripheral long-lasting and opioid …
rattlesnake Crotalus durissus terrificus, induces a peripheral long-lasting and opioid …
Crotalphine, a novel potent analgesic peptide from the venom of the South American rattlesnake Crotalus durissus terrificus
K Konno, G Picolo, VP Gutierrez, P Brigatte… - Peptides, 2008 - Elsevier
We have shown that the venom of the South American rattlesnake Crotalus durissus
terrificus induces a long-lasting antinociceptive effect mediated by activation of κ-and δ …
terrificus induces a long-lasting antinociceptive effect mediated by activation of κ-and δ …
Involvement of ATP-sensitive K+ channels in the peripheral antinociceptive effect induced by dipyrone
DP Alves, IDG Duarte - European journal of pharmacology, 2002 - Elsevier
We evaluated the effect of several K+ channel blockers on the peripheral antinociception
induced by dipyrone using the rat paw pressure test, in which sensitivity is increased by …
induced by dipyrone using the rat paw pressure test, in which sensitivity is increased by …
ATP-gated K+ channel openers enhance opioid antinociception: indirect evidence for the release of endogenous opioid peptides
AB Lohmann, SP Welch - European journal of pharmacology, 1999 - Elsevier
The ATP-gated K+ channel openers—diazoxide, levcromakalim and morphine—enhance
K+ efflux by opening ATP-gated K+ channels, thereby inducing cell hyperpolarization …
K+ efflux by opening ATP-gated K+ channels, thereby inducing cell hyperpolarization …
Involvement of ATP‐sensitive K+ channels in the peripheral antinociceptive effect induced by ketamine
TRL Romero, IDG Duarte - Veterinary anaesthesia and analgesia, 2013 - Elsevier
Objective To investigate the contribution of K+ channels on peripheral antinociception
induced by ketamine. Study design Prospective experimental study. Animals 110 male …
induced by ketamine. Study design Prospective experimental study. Animals 110 male …