Dendrimers for drug solubilization, dissolution and bioavailability

A Chauhan, B Anton, MK Singh - Pharmaceutical Applications of …, 2020 - Elsevier
Solubility of a drug influences the behavior of compounds in biomedical applications. Poor
solubility of drugs and hydrophobicity along with other bioactive compounds limit their …

Dendrimer for solubility enhancement

B Gorain, M Pandey, H Choudhury, GK Jain… - Dendrimer-based …, 2021 - Elsevier
A drug is effective in their molecular form; thus solubility in the biological fluid is important.
Pharmaceutical researchers are continuously working on the improvement of solubility of …

Dendrimers for enhanced drug solubilization

S Svenson, AS Chauhan - Nanomedicine, 2008 - Taylor & Francis
Approximately 40% of newly developed drugs are rejected by the pharmaceutical industry
and will never benefit a patient because of low water solubility. Another 17% of launched …

Role of Dendrimer in Drug Solubilisation-A Review

RV Movliya, PM Patel - Drug Delivery Letters, 2019 - ingentaconnect.com
Objective: Dendrimers, a new class of synthetic polymers proved themselves very useful
tools for biomedical application due to their unique characteristics including water solubility …

Impact of dendrimers on solubility of hydrophobic drug molecules

S Choudhary, L Gupta, S Rani, K Dave… - Frontiers in …, 2017 - frontiersin.org
Adequate aqueous solubility has been one of the desired properties while selecting drug
molecules and other bio-actives for product development. Often solubility of a drug …

Dendrimers for enhanced drug solubilization

NK Jain, RK Tekade - Drug Delivery Strategies for Poorly Water …, 2013 - Wiley Online Library
Dendrimers are synthetic, absolutely branched, mono‐disperse, unimolecular micellar
architectures with nanometeric dimensions. They are compartmentalized structures with …

The use of dendrimers to optimize the physicochemical and therapeutic properties of drugs

N Stieger, W Liebenberg, ME Aucamp… - … -based drug delivery …, 2012 - Wiley Online Library
Dendrimers are increasingly being investigated as pharmaceutical delivery systems (Figs.
3.1 and 3.2) because of their ability to: improve the solubility and bioavailability of drugs; …

Dendrimers for drug delivery purposes

J Pan, SA Attia, N Filipczak, VP Torchilin - … Biomaterials for Advanced Drug …, 2020 - Elsevier
Currently, various types of nanocarriers have been widely used to deliver bioactive
compounds to improve the specificity/effectiveness of the active compound. Among these …

Application of dendrimer–drug complexation in the enhancement of drug solubility and bioavailability

NK Jain, U Gupta - Expert opinion on drug metabolism & toxicology, 2008 - Taylor & Francis
Dendrimers are 3D, hyperbranched, tree-like polymers having immense potential in drug
delivery, targeting, diagnosis and as carriers for DNA/gene delivery. Dendrimers have …

[PDF][PDF] PAMAM Dendrimers mediated solubility enhancement of poorly soluble drugs: a concise review

SP Gautam, AK Gupta, SUD Wani, N Malviya… - Int. J. Pharm. Drug …, 2015 - researchgate.net
High solubility, high permeability and good stability are basic prerequisites for achieving the
bioavailability and hence therapeutic effectiveness. Newly developed drugs having poor …