In a way not possible in humans, cancer prevention scientists have used animal models to
study the role of genes, molecular pathways and networks, and environmental factors that …

This perspective on Romero et al.(beginning on p. 792 in this issue of the journal) discusses
the available animal models of ovarian cancer, including the laying hen, non-human …

Ovarian cancer is a lethal gynecological cancer causing cancer-related deaths in women
worldwide. It is difficult to diagnosis at an early stage when more than 90% patients can be …

Often referred to as the silent killer, ovarian cancer is the most lethal gynecologic
malignancy. This disease rarely shows any physical symptoms until late stages and no …

Objective. A significant obstacle confronting the evaluation of potential chemopreventive
compounds in ovarian carcinoma is the absence of an animal model of spontaneous …

The domestic laying hen is the only non-human animal that spontaneously develops ovarian
cancer with a high prevalence. Hens ovulate prolifically, and this has made the hen …

Selection of appropriate animal models is essential to the advancement of basic and clinical
research. This chapter provides an overview of the reproductive biology of the chicken …

The high mortality rate due to ovarian cancer (OVCA) is attributed to the lack of an effective
early detection method. Because of the nonspecificity of symptoms at early stage, most of the …

We examined alterations in the p53 tumor suppressor gene and the ras and HER-2/neu
oncogenes in chicken ovarian cancers to determine if these tumors have genetic alterations …

The hen is an attractive animal model for in vivo testing of agents that thwart ovarian
carcinogenesis because ovarian cancer in the domestic hen features clinical and molecular …