Anti-CD2 monoclonal antibodies prevent the induction of experimental autoimmune myocarditis

T Inomata, T Watanabe, M Haga, H Hirahara… - Japanese heart …, 2000 - jstage.jst.go.jp
We investigated the effect of a monoclonal antibody against CD2 molecules (OX34) in
preventing the induction of experimental autoimmune myocarditis (EAM) induced by …

Immune tolerance to cardiac myosin induced by anti-CD4 monoclonal antibody in autoimmune myocarditis rats

W Qing-Qing, W Yu-Lin, Y Hai-Tao, L Feng-Qin… - Journal of Clinical …, 2006 - Springer
Autoimmune myocarditis is a T-cell-mediated autoimmune disease. CD4-positive T cells are
believed to be the most important for the initiation and mediation of the disease. This study …

Anti‐αβ T cell receptor antibody prevents the progression of experimental autoimmune myocarditis

H Hanawa, M Kodama, T Inomata… - Clinical & …, 1994 - Wiley Online Library
We investigated the effects of anti‐αβ T cell receptor antibody in rat experimental
autoimmune myocarditis (HAM), using a new animal model of autoimmune myocarditis …

Experimental autoimmune myocarditis

M Kodama, T Izumi - Acta medica et biologica, 1991 - cir.nii.ac.jp
抄録 Recently, we have established a novel experimental model for autoimmune
myocarditis. Acute serious myocarditis can be induced in Lewis rats by immunization with …

Myosin-induced acute myocarditis is a T cell-mediated disease.

SC Smith, PM Allen - Journal of immunology (Baltimore, Md.: 1950), 1991 - journals.aai.org
The heart is a target organ in several autoimmune diseases, and therefore it is important to
understand more about the effector cells involved in immune-mediated mechanisms of …

In vivo deposition of myosin-specific autoantibodies in the hearts of mice with experimental autoimmune myocarditis.

DA Neumann, JR Lane, SM Wulff, GS Allen… - … (Baltimore, Md.: 1950 …, 1992 - journals.aai.org
Experimental autoimmune myocarditis (EAM) is elicited in certain strains of mice by
immunizing with mouse cardiac myosin. Concomitant with the onset of myocardial …

The induction of experimental autoimmune myocarditis in mice lacking CD4 or CD8 molecules [corrected]

JM Penninger, N Neu, E Timms, VA Wallace… - The Journal of …, 1993 - rupress.org
Experimental induction of most autoimmune diseases appears to depend on the activation
of CD4+ T helper cells, while CD8+ lymphocytes may have a role in disease progression. To …

Localization of porcine cardiac myosin epitopes that induce experimental autoimmune myocarditis.

T Inomata, H Hanawa, T Miyanishi, E Yajima… - Circulation …, 1995 - europepmc.org
Porcine cardiac myosin induced severe myocarditis in Lewis rats, similar to that seen after
immunization with human or rat cardiac myosin. We investigated the localization of …

Analysis of heart-infiltrating T-cell clonotypes in experimental autoimmune myocarditis in rats

H Hanawa, T Inomata, H Sekikawa, T Abo… - Circulation …, 1996 - Am Heart Assoc
Experimental autoimmune myocarditis (EAM) resembles the lethal giant cell myocarditis
seen in humans, and the recurrent forms lead to dilated cardiomyopathy (DCM). EAM in rats …

In vivo lymphocyte-mediated myocardial injuries demonstrated by adoptive transfer of experimental autoimmune myocarditis.

M Kodama, Y Matsumoto, M Fujiwara - Circulation, 1992 - Am Heart Assoc
BACKGROUND To elucidate the mechanisms of immune-related myocardial injuries, we
examined whether autoimmune myocarditis was passively transferable by use of humoral or …