In vitro radioligand binding studies were carried out in rat brain membranes to assess the
affinity of various reuptake inhibitors for the serotonin (5-hydroxytryptamine, 5-HT) and the …

A 68-kDa glycoprotein bearing the biological activity of the plasma membrane serotonin (5-
hydroxytryptamine, 5-HT) transporter has been purified from human blood platelets, a …

A rapidly growing body of data suggests that abnormalities in serotonergic function might be
involved in the pathophysiology of schizophrenia and that serotonergic mechanisms play a …

Previous studies investigating the serotonin transporter (SERT) in depression have been
inconsistent and included a large proportion of subjects who had committed suicide. In …

1 The present study was undertaken to characterise the relationship between in vivo brain
serotonin transporter (SERT) binding, plasma concentration and pharmacological effect of …

Serotonin is a neurotransmitter in the central nervous system which has been implicated in
the aetiology and pathogenesis of affective disorders. The serononergic system also plays …

An investigation of the site of interaction of a variety of tricyclic and nontricyclic 5-HT uptake
inhibitors with the neuronal sodium-dependent 5-HT transporter was undertaken. The …

The objective of this study was to examine the turnover of the serotonin transporter (SERT)
by determining its production rate (r), degradation rate constant (k) and half-life of recovery …

The serotonergic system plays a role in mediating the effects of several drugs of abuse. 1, 2
In addition, it has been shown to play a major role in the neurobiology of mood disorders. 3 …

Neurochemical imbalance between noradrenergic and serotonergic systems has been
postulated to underlie the pathophysiology of psychiatric illnesses involving mood disorders …