[HTML][HTML] PL03. 05: BRAIN: a phase III trial comparing WBI and chemotherapy with icotinib in NSCLC with brain metastases harboring EGFR mutations (CTONG 1201)
YL Wu, JJ Yang, C Zhou, J Feng, S Lu, Y Song… - Journal of Thoracic …, 2017 - jto.org
Background Non-small cell lung cancer (NSCLC) with brain metastases (M) had a poor
prognosis. Whole brain irradiation (WBI) is a standard of care for this critical medical …
prognosis. Whole brain irradiation (WBI) is a standard of care for this critical medical …
A phase II study of icotinib and whole-brain radiotherapy in Chinese patients with brain metastases from non-small cell lung cancer
Y Fan, Z Huang, L Fang, L Miao, L Gong, H Yu… - Cancer chemotherapy …, 2015 - Springer
Purpose Icotinib is a new first-generation epidermal growth factor receptor (EGFR) tyrosine
kinase inhibitors. A phase II study was conducted to evaluate the efficacy and safety of …
kinase inhibitors. A phase II study was conducted to evaluate the efficacy and safety of …
Icotinib is as efficacious as gefitinib for brain metastasis of EGFR mutated non-small-cell lung cancer
K Liu, G Jiang, A Zhang, Z Li, J Jia - BMC cancer, 2020 - Springer
Background The prognosis of non-small-cell lung cancer (NSCLC) with brain metastases is
very poor. Currently, therapeutic methods for this patient population include whole-brain …
very poor. Currently, therapeutic methods for this patient population include whole-brain …
Effects of icotinib with and without radiation therapy on patients with EGFR mutant non-small cell lung cancer and brain metastases
Y Fan, Y Xu, L Gong, L Fang, H Lu, J Qin, N Han… - Scientific reports, 2017 - nature.com
EGFR-TKIs and radiation therapy (RT) are the principal treatment for patients with brain
metastases (BM) and EGFR mutant NSCLC. However, the optimal use of brain RT for …
metastases (BM) and EGFR mutant NSCLC. However, the optimal use of brain RT for …
Multiple treatment modalities for brain metastasis in patients with EGFR-mutant non-small-cell lung cancer
H Wang, X Yu, Y Fan, Y Jiang - OncoTargets and therapy, 2018 - Taylor & Francis
Background There are many controversies concerning the best management of epidermal
growth factor receptor (EGFR)-mutant non-small-cell lung cancer (NSCLC) patients with …
growth factor receptor (EGFR)-mutant non-small-cell lung cancer (NSCLC) patients with …
[HTML][HTML] Clinical outcome of tyrosine kinase inhibitors alone or combined with radiotherapy for brain metastases from epidermal growth factor receptor (EGFR) mutant …
Q Zhu, Y Sun, Y Cui, K Ye, C Yang, D Yang, J Ma… - Oncotarget, 2017 - ncbi.nlm.nih.gov
This study compared treatment outcomes between TKI monotherapy and TKI administration
combined with brain radiotherapy (TKI+ RT) in 133 non-small cell lung cancer (NSCLC) …
combined with brain radiotherapy (TKI+ RT) in 133 non-small cell lung cancer (NSCLC) …
Combination of EGFR-Directed Tyrosine Kinase Inhibitors (EGFR-TKI) with Radiotherapy in Brain Metastases from Non-Small Cell Lung Cancer: A 2010–2019 …
Simple Summary Radiotherapy, in the form of either whole-brain radiotherapy (WBRT) or
stereotactic radiosurgery (SRS), continues as the standard of care for patients of non-small …
stereotactic radiosurgery (SRS), continues as the standard of care for patients of non-small …
Paradigm shift of therapeutic management of brain metastases in EGFR-mutant non-small cell lung cancer in the era of targeted therapy
A Sekine, H Satoh - Medical Oncology, 2017 - Springer
Non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR)
mutations commonly present brain metastases (BM) at the time of NSCLC diagnosis or …
mutations commonly present brain metastases (BM) at the time of NSCLC diagnosis or …
Impact of whole brain radiation therapy on CSF penetration ability of Icotinib in EGFR-mutated non-small cell lung cancer patients with brain metastases: results of …
L Zhou, J He, W Xiong, Y Liu, J Xiang, Q Yu, M Liang… - Lung Cancer, 2016 - Elsevier
Objectives Whole-brain radiation therapy (WBRT) and epidermal growth factor receptor
tyrosine kinase inhibitors (EGFR-TKIs) are both treatment options for EGFR-mutated non …
tyrosine kinase inhibitors (EGFR-TKIs) are both treatment options for EGFR-mutated non …
A comparative analysis of EGFR mutation status in association with the efficacy of TKI in combination with WBRT/SRS/surgery plus chemotherapy in brain metastasis …
L Cai, J Zhu, X Zhang, S Lin, X Su, P Lin, K Chen… - Journal of neuro …, 2014 - Springer
We proposed to identify the efficacy of an epidermal growth factor receptor (EGFR) tyrosine
kinase inhibitor (TKI) using whole brain radiotherapy (WBRT)/stereotactic radiosurgery …
kinase inhibitor (TKI) using whole brain radiotherapy (WBRT)/stereotactic radiosurgery …