Shiga toxins are a group of type 2 ribosome-inactivating proteins (RIPs) produced in several
types of bacteria. The toxins possess an AB 5 structure, which comprises a catalytic A chain …

Shiga and Shiga-like toxins (Stxs) are produced by bacteria able to cause infectious disease
(Karmali, 2004b; Karmali, 2004a; O'Loughlin and Robins-Browne, 2001). These protein …

Shiga toxin and Shiga-like toxins belong to the group of protein toxins which have a moiety
that binds to the cell surface and another enzymatically active moiety that after entry into the …

Shiga toxins are virulence factors produced by the bacteria Shigella dysenteriae and certain
strains of Escherichia coli. There is currently no available treatment for disease caused by …

Shiga toxin is a potent toxin produced by Shigella dysenteriae type 1 strains. The toxin has
three biologic activities—cytotoxicity, enterotoxicity, and neurotoxicity—and one known …

Cleavage of Shiga toxin A-fragment at a highly trypsin-sensitive site increases its enzymatic
activity. To investigate the role of this cleavage site in intoxication of cells, we studied the …

Shiga toxin consists of an enzymatically active A-chain and a pentameric binding subunit.
The A-chain has a trypsin-sensitive region, and upon cleavage two disulfide bonded …

Bacterial Shiga toxin and related toxins are endocytosed by higher eukaryotic cells. The
toxin protein is then transported via the Golgi apparatus to the endoplasmic reticulum (ER) …

The effect of Shiga toxin with mutations in the A fragment has been tested on cells in order to
get more information about the processing of the A fragment during entry into the cytosol. A …

Shiga toxin-producing Escherichia coli is an emergent pathogen that can induce haemolytic
uraemic syndrome. The toxin has received considerable attention not only from …