Estrogen deficiency decreases ischemic tolerance in the aged rat heart: roles of PKCδ, PKCε, Akt, and GSK3β
JC Hunter, JC Kostyak, JL Novotny… - American Journal …, 2007 - journals.physiology.org
The mechanisms underlying the age-dependent reversal of female cardioprotection are
poorly understood and complicated by findings that estrogen replacement is ineffective at …
poorly understood and complicated by findings that estrogen replacement is ineffective at …
Local delivery of a PKCε-activating peptide limits ischemia reperfusion injury in the aged female rat heart
TS Lancaster, SJ Jefferson… - American Journal of …, 2011 - journals.physiology.org
Reduced efficacy of cardioprotective interventions in the aged female heart, including
estrogen replacement, highlights the need for alternative therapeutics to reduce myocardial …
estrogen replacement, highlights the need for alternative therapeutics to reduce myocardial …
Rapid estrogen receptor-α activation improves ischemic tolerance in aged female rats through a novel protein kinase Cε-dependent mechanism
JL Novotny, AM Simpson, NJ Tomicek… - …, 2009 - academic.oup.com
The effects of estrogen deficiency on the loss of cardioprotection with advancing age are
complex and poorly understood. A major focus of the current study was to uncover a …
complex and poorly understood. A major focus of the current study was to uncover a …
Age-related differences in cardiac ischemia–reperfusion injury: effects of estrogen deficiency
DH Korzick, TS Lancaster - Pflügers Archiv-European Journal of …, 2013 - Springer
Despite conflicting evidence for the efficacy of hormone replacement therapy in
cardioprotection of postmenopausal women, numerous studies have demonstrated …
cardioprotection of postmenopausal women, numerous studies have demonstrated …
Estrogen receptor β mediates increased activation of PI3K/Akt signaling and improved myocardial function in female hearts following acute ischemia
M Wang, Y Wang, B Weil… - American Journal …, 2009 - journals.physiology.org
Females have a lower incidence of heart failure and improved survival after myocardial
ischemia-reperfusion (I/R) compared with males. Although estrogen-suppressed …
ischemia-reperfusion (I/R) compared with males. Although estrogen-suppressed …
Activation of a novel estrogen receptor, GPER, is cardioprotective in male and female rats
AM Deschamps, E Murphy - American Journal of …, 2009 - journals.physiology.org
Premenopausal females have a lower incidence of cardiovascular disease than their male
counterparts, but the mechanism is unclear. Estrogen has been thought to signal through …
counterparts, but the mechanism is unclear. Estrogen has been thought to signal through …
G protein-coupled estrogen receptor 1 mediates acute estrogen-induced cardioprotection via MEK/ERK/GSK-3β pathway after ischemia/reperfusion
Three types of estrogen receptors (ER) exist in the heart, Esr1, Esr2 and the G protein-
coupled estrogen receptor 1, Gper1. However, their relative importance in mediating …
coupled estrogen receptor 1, Gper1. However, their relative importance in mediating …
Estrogen receptor-α mediates acute myocardial protection in females
M Wang, P Crisostomo, GM Wairiuko… - American Journal of …, 2006 - journals.physiology.org
Sex differences in myocardial recovery have been reported after acute ischemia and
reperfusion injury. Estrogen and the estrogen receptor are critical determinants of …
reperfusion injury. Estrogen and the estrogen receptor are critical determinants of …
Inhibition of programmed necrosis limits infarct size through altered mitochondrial and immune responses in the aged female rat heart
AM Garvin, MA Jackson… - American Journal of …, 2018 - journals.physiology.org
Both advancing age and estrogen loss exacerbate acute myocardial infarction in the female
heart. However, the mechanistic underpinnings of age-related differences in cell death after …
heart. However, the mechanistic underpinnings of age-related differences in cell death after …
Estrogen receptor beta does not influence ischemic tolerance in the aged female rat heart
NJ Tomicek, JL Miller‐Lee, JC Hunter… - Cardiovascular …, 2013 - Wiley Online Library
Introduction: Ischemic heart disease remains the leading cause of morbidity and mortality in
aged women, with a 2‐to 3‐fold increase in incidence following menopause. Clinical trials …
aged women, with a 2‐to 3‐fold increase in incidence following menopause. Clinical trials …
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