Together with the permeability, the solubility behavior of a drug is a key determinant of its
oral bioavailability. There have always been certain drugs for which solubility has presented …

This article investigates the aqueous solubility of the poorly soluble drug candesartan
cilexetil (CC) in the presence of poly (amidoamine)(PAMAM) dendrimers. The effect of …

Drug solubility could affect the therapeutic use of a drug because the biological activity of a
drug is only possible if some fraction of a dissolved drug can permeate and overcome …

A drug is effective in their molecular form; thus solubility in the biological fluid is important.
Pharmaceutical researchers are continuously working on the improvement of solubility of …

The aim of this study was to investigate the effect of low generation (G0–G3)
ethylenediamine (EDA) core poly (amidoamine)(PAMAM) dendrimers on the aqueous …

In the last two decades, dendrimers have proven their capabilities in drug delivery, physical
stabilization of the drug, solubility enhancement of the poorly soluble drugs and gene …

Adequate aqueous solubility has been one of the desired properties while selecting drug
molecules and other bio-actives for product development. Often solubility of a drug …

In this study, a series of aspartate based dendrimers with different cores were synthesized in
a convergent approach and well characterized by NMR and MS techniques. The aqueous …

Approximately 40% of newly developed drugs are rejected by the pharmaceutical industry
and will never benefit a patient because of low water solubility. Another 17% of launched …

The complexation of the practically insoluble drug furosemide (acidic pKa 3.22) with lower
generation PAMAM dendrimers showed a significant release dependence on the ionization …