Severe sepsis leading to shock is the principal cause of death in non-cardiac intensive care
units. This condition develops because of a dysregulation in host responses, such that the …

The clinical syndrome of sepsis encompasses a highly heterogeneous group of clinical
disorders, varying with respect to the site, bacteriology, and even presence of infection and …

Sepsis and septic shock lead to considerable morbidity and mortality in developed and
developing countries. Despite advances in understanding the innate immune events that …

Sepsis is currently defined as a life-threatening organ dysfunction caused by a dysregulated
host response to infection, and it affects over 25 million people every year. Even more …

Therapy for severe sepsis and septic shock remains a major unmet medical need and novel
treatments to regulate the disordered inflammatory response in sepsis are needed if …

Introduction: Sepsis is characterized by a dysregulated host response to infection. Sepsis-
associated morbidity/mortality demands concerted research efforts toward therapeutic …

The underlying principles of sepsis therapy have remained unchanged for decades. These
include: prompt institution of antimicrobial agents aimed at the inciting pathogen, source …

Sepsis is a life-threatening organ dysfunction syndrome caused by dysregulated host
responses to infection. Not only does sepsis pose a serious hazard to human health, but it …

Recent advances in sepsis therapy exclusively involve improvements in supportive care,
while sepsis mortality rates remain disturbingly high at 30%. These persistently high sepsis …

Our understanding of sepsis and its resultant outcomes remains a paradox. On the one
hand, we know more about the pathophysiology of sepsis than ever before. However, this …