Acetaminophen (APAP) overdose-induced fatal hepatotoxicity is majorly characterized by
overwhelmingly increased oxidative stress while enhanced nuclear factor-erythroid 2 …

Rosmarinic acid (RA) is a natural polyphenol with various biological activities, such as anti-
oxidative, anti-fibrotic, and hepatoprotective properties. The objective of this study was to …

Acetaminophen (APAP) overdose‐induced acute liver injury (ALI) causes hepatocyte cell
death, oxidative stress, and inflammation. Oridonin (Ori), a covalent NLRP3‐inflammasome …

Background: Acetaminophen (APAP) overdose results in the production of reactive oxygen
species (ROS), induces hepatocyte necrosis, and leads to acute liver failure. Atractylenolide …

Acetaminophen (APAP)-induced acute liver injury (ALI) is the principal cause of acute liver
failure (ALF) in some countries including the United States and with few available …

Acetaminophen (APAP)-induced liver injury is a common hepatic disease resulting from
drug abuse. Few targeted treatments are available clinically nowadays. The flower bud of …

Acetaminophen (APAP) overdose is the leading cause of acute liver failure (ALF) in the
Western world, with limited treatment opportunities. 3, 5, 7, 4′-Tetrahydroxyflavanone …

Hepatotoxicity due to acetaminophen (APAP) overdose is a leading cause of drug-induced
acute liver failure in clinic. Chlorogenic acid (CGA), a dietary polyphenol, was reported to …

Severe acetaminophen (APAP)‐induced hepatic damage is the second most common
cause for hepatic transplantation. Clinically, hepatic damage caused by APAP is treated …

Despite its effectiveness in treating inflammatory diseases and various malignancies,
methotrexate (MTX) is well known to cause hepatotoxicity, which involves increased …