Acetaminophen (APAP) overdose may lead to the formation of oxidative stress, hepatocyte
apoptosis and necrosis, and, eventually result in acute liver failure. Escin, a major extracted …

Isolongifolene (ISO) has antioxidant, anti-inflammatory, anticancer, and neuroprotective
effects; however, it is unclear whether ISO has a protective effects against liver …

Acetaminophen (APAP) overdose is one of the most common causes of drug‐induced acute
liver failure in humans. To investigate the hepatoprotective effect of salvianolic acid C (SAC) …

Puerarin (Pue) is a kind of isoflavone compound extracted from Pueraria lobata, which has
significant antioxidant activity. Excessive use of acetaminophen (APAP) can cause oxidative …

Isoorientin (ISO) is considered one of the most important flavonoid-like compounds
responsible for health benefits, including the prevention of liver damage as well as …

Acetaminophen (APAP)-induced liver injury (AILI) is the main cause of acute liver failure in
the developed countries. The present study aimed to evaluate the therapeutic efficacy of …

Background Limonin, a bioactive compound from citrus plants, exerts antioxidant activities,
however its therapeutic potential in acetaminophen (APAP)-induced hepatotoxicity remains …

Acetaminophen (APAP) overdose would lead to liver toxicity and even acute liver failure in
severe cases by triggering an inflammatory response and oxidative stress. Sesamin has …

Ethnopharmacological relevance Oroxyloside is a natural flavonoid isolated from Scutellaria
baicalensis Georgi (Lamiaceae) which is a Chinese herb widely used for liver diseases …

Summary Acetaminophen (N-acetyl-p-aminophenol, APAP) overdose causes hepatotoxicity,
even liver failure, and oxidative stress plays pivotal role in its pathogenesis. Nicotinic acid …