Background: Drug-induced liver injury (DILI), represented by acetaminophen (APAP), is a
common cause of acute liver failure in clinics. Paeoniflorin (PF) has been proven to …

The vast majority of drug-induced liver injury is mainly attributed to acetaminophen (APAP)
overdose. Salvianolic acid A (Sal A), a powerful water-soluble compound obtained from …

Background Acetaminophen (paracetamol, APAP) overdose is the principal cause of acute
liver injury (ALI) that leads to liver failure typified with oxidative stress, mitochondrial and …

Background Oxidative stress-triggered fatal hepatotoxicity is an essential pathogenic factor
in acute liver failure (ALF). Aims To investigate the protective effect of daphnetin (Daph) on …

Acetaminophen (APAP) overdose is very common worldwide and has been widely
recognized as the leading cause of drug-induced liver injury in the Western world. In our …

The alleviation of oxidative stress is considered an effective treatment for acetaminophen
(APAP)-induced acute liver injury (AILI). However, it remains unknow whether the potential …

Emodin (EMO), the main bioactive component of Polygonum multiflorum, Rheum palmatum,
Aloe vera and Cassia acutifolia, can cause severe hepatotoxicity. Isoliquiritigenin (ISL), a …

Naringin is a dihydroflavone which was found in citrus fruits. Previous studies have indicated
the antiapoptotic, antioxidative stress, and anti‐inflammatory effects of naringin. It can …

Aim Acetaminophen (APAP) overdose is the most frequent cause of drug-induced liver
damage. Magnolia officinalis is a traditional hepatoprotective Chinese medicine and …

Oxidative stress plays a crucial role in the pathogenesis of acute pancreatitis (AP).
Isoliquiritigenin (ISL) is a flavonoid monomer with confirmed antioxidant activity. However …