Confusoside (CF), a major chemical compound in the leaves of Anneslea fragrans Wall., is a
dihydrochalcone glycoside with excellent antioxidant and anti-inflammatory effects …

Summary Acetaminophen (N-acetyl-p-aminophenol, APAP) overdose causes hepatotoxicity,
even liver failure, and oxidative stress plays pivotal role in its pathogenesis. Nicotinic acid …

Ethnopharmacological relevance Oroxyloside is a natural flavonoid isolated from Scutellaria
baicalensis Georgi (Lamiaceae) which is a Chinese herb widely used for liver diseases …

The vast majority of drug-induced liver injury is mainly attributed to acetaminophen (APAP)
overdose. Salvianolic acid A (Sal A), a powerful water-soluble compound obtained from …

Background: Drug-induced liver injury (DILI), represented by acetaminophen (APAP), is a
common cause of acute liver failure in clinics. Paeoniflorin (PF) has been proven to …

Acetaminophen (APAP) overdose is very common worldwide and has been widely
recognized as the leading cause of drug-induced liver injury in the Western world. In our …

Background Acetaminophen (paracetamol, APAP) overdose is the principal cause of acute
liver injury (ALI) that leads to liver failure typified with oxidative stress, mitochondrial and …

Background Oxidative stress-triggered fatal hepatotoxicity is an essential pathogenic factor
in acute liver failure (ALF). Aims To investigate the protective effect of daphnetin (Daph) on …

The alleviation of oxidative stress is considered an effective treatment for acetaminophen
(APAP)-induced acute liver injury (AILI). However, it remains unknow whether the potential …

Emodin (EMO), the main bioactive component of Polygonum multiflorum, Rheum palmatum,
Aloe vera and Cassia acutifolia, can cause severe hepatotoxicity. Isoliquiritigenin (ISL), a …