Droplet array for screening acute behaviour response to chemicals in Caenorhabditis elegans

G Aubry, H Lu - Lab on a Chip, 2017 - pubs.rsc.org
Caenorhabditis elegans is an excellent model organism for studying chemosensation as a
significant part of its nervous system and genome are devoted to the detection of chemical …

Advances in C. áelegans behavior research with microfluidic devices and its future prospects in the evaluation of exogenous pollutants

X Zhang, J Sun, X Yuan, X Lu, X Sun - TrAC Trends in Analytical Chemistry, 2021 - Elsevier
The nematode Caenorhabditis elegans (C. áelegans) is characterized by small size, a
transparent body, and a simple structure. However, traditional techniques (eg, sorting and …

Microfluidic systems for high-throughput and high-content screening using the nematode Caenorhabditis elegans

M Cornaglia, T Lehnert, MAM Gijs - Lab on a Chip, 2017 - pubs.rsc.org
In a typical high-throughput drug screening (HTS) process, up to millions of chemical
compounds are applied to cells cultured in well plates, aiming to find molecules that exhibit …

Microfluidic tools for developmental studies of small model organisms–nematodes, fruit flies, and zebrafish

H Hwang, H Lu - Biotechnology journal, 2013 - Wiley Online Library
Studying the genetics of development with small model organisms such as the zebrafish
(Danio Rerio), the fruit fly (Drosophila melanogaster), and the soil‐dwelling nematode …

Droplet-based microfluidic system for individual Caenorhabditis elegans assay

W Shi, J Qin, N Ye, B Lin - Lab on a Chip, 2008 - pubs.rsc.org
A droplet-based microfluidic system integrating a droplet generator and a droplet trap array
is described for encapsulating individual Caenorhabditis elegans into a parallel series of …

[HTML][HTML] Microfluidic Device for Microinjection of Caenorhabditis elegans

R Ghaemi, J Tong, BP Gupta, PR Selvaganapathy - Micromachines, 2020 - mdpi.com
Microinjection is an established and reliable method to deliver transgenic constructs and
other reagents to specific locations in C. elegans worms. Specifically, microinjection of a …

Droplet microfluidics for characterizing the neurotoxin-induced responses in individual Caenorhabditis elegans

W Shi, H Wen, Y Lu, Y Shi, B Lin, J Qin - Lab on a Chip, 2010 - pubs.rsc.org
A droplet-based microfluidic device integrated with a novel floatage-based trap array and a
tapered immobilization channel array was presented for characterizing the neurotoxin …

[HTML][HTML] A programmable microvalve-based microfluidic array for characterization of neurotoxin-induced responses of individual C. elegans

H Ma, L Jiang, W Shi, J Qin, B Lin - Biomicrofluidics, 2009 - pubs.aip.org
The soil dwelling nematode Caenorhabditis elegans (C. elegans) is an excellent model
organism for the study of numerous disease including neurodegenerative disease. In this …

C. elegans in high-throughput drug discovery

LP O'Reilly, CJ Luke, DH Perlmutter… - Advanced drug delivery …, 2014 - Elsevier
Caenorhabditis elegans has been proven to be a useful model organism for investigating
molecular and cellular aspects of numerous human diseases. More recently, investigators …

Microfluidic platform with spatiotemporally controlled micro-environment for studying long-term C. elegans developmental arrests

W Zhuo, H Lu, PT McGrath - Lab on a Chip, 2017 - pubs.rsc.org
Animals' long-term survival is dependent on their ability to sense, filter and respond to their
environment at multiple timescales. For example, during development, animals integrate …