A microfluidic platform for high-sensitivity, real-time drug screening on C. elegans and parasitic nematodes
JA Carr, A Parashar, R Gibson, AP Robertson… - Lab on a Chip, 2011 - pubs.rsc.org
This paper describes a new microfluidic platform for screening drugs and their dose
response on the locomotion behavior of free living nematodes and parasitic nematodes. The …
response on the locomotion behavior of free living nematodes and parasitic nematodes. The …
Culturing Caenorhabditis elegans in axenic liquid media and creation of transgenic worms by microparticle bombardment
TK Samuel, JW Sinclair, KL Pinter, I Hamza - JoVE (Journal of Visualized …, 2014 - jove.com
In this protocol, we present the required materials, and the procedure for making modified C.
elegans Habituation and Reproduction media (mCeHR). Additionally, the steps for exposing …
elegans Habituation and Reproduction media (mCeHR). Additionally, the steps for exposing …
Automated phenotyping of Caenorhabditis elegans embryos with a high-throughput-screening microfluidic platform
The nematode Caenorhabditis elegans has been extensively used as a model multicellular
organism to study the influence of osmotic stress conditions and the toxicity of chemical …
organism to study the influence of osmotic stress conditions and the toxicity of chemical …
Laterally Orienting C. elegans Using Geometry at Microscale for High-Throughput Visual Screens in Neurodegeneration and Neuronal Development Studies
IC Cáceres, N Valmas, MA Hilliard, H Lu - PloS one, 2012 - journals.plos.org
C. elegans is an excellent model system for studying neuroscience using genetics because
of its relatively simple nervous system, sequenced genome, and the availability of a large …
of its relatively simple nervous system, sequenced genome, and the availability of a large …
An Automated Microfluidic System for Morphological Measurement and Size-Based Sorting of C. Elegans
This paper reports a vision-based automated microfluidic system for morphological
measurement and size-based sorting of the nematode worm C. elegans. Exceeding the …
measurement and size-based sorting of the nematode worm C. elegans. Exceeding the …
Amplitude-modulated sinusoidal microchannels for observing adaptability in C. elegans locomotion
In this paper, we present a movement-based assay to observe adaptability in
Caenorhabditis elegans locomotion behavior. The assay comprises a series of sinusoidal …
Caenorhabditis elegans locomotion behavior. The assay comprises a series of sinusoidal …
Microfluidic immobilization of physiologically active Caenorhabditis elegans
CL Gilleland, CB Rohde, F Zeng, MF Yanik - Nature protocols, 2010 - nature.com
We present a protocol for building and operating a microfluidic device for mechanical
immobilization of Caenorhabditis elegans in its physiologically active state. The system can …
immobilization of Caenorhabditis elegans in its physiologically active state. The system can …
Highly efficient microfluidic sorting device for synchronizing developmental stages of C. elegans based on deflecting electrotaxis
C. elegans as a powerful model organism has been widely used in fundamental biological
studies. Many of these studies frequently need a large number of different stage …
studies. Many of these studies frequently need a large number of different stage …
Automated fluid delivery from multiwell plates to microfluidic devices for high-throughput experiments and microscopy
RC Lagoy, DR Albrecht - Scientific reports, 2018 - nature.com
High-throughput biological and chemical experiments typically use either multiwell plates or
microfluidic devices to analyze numerous independent samples in a compact format …
microfluidic devices to analyze numerous independent samples in a compact format …
Microfluidic system for Caenorhabditis elegans culture and oxygen consumption rate measurements
R Krenger, M Cornaglia, T Lehnert, MAM Gijs - Lab on a Chip, 2020 - pubs.rsc.org
Mitochondrial respiration is a key signature for the assessment of mitochondrial functioning
and mitochondrial dysfunction is related to many diseases including metabolic syndrome …
and mitochondrial dysfunction is related to many diseases including metabolic syndrome …