Functional characterization of cloned intrahepatic, hepatitis B virus nucleoprotein-specific helper T cell lines.

C Ferrari, MU Mondelli, A Penna… - … (Baltimore, Md.: 1950 …, 1987 - journals.aai.org
We have previously reported the establishment and preliminary characterization of
polyclonal hepatitis B virus (HBV) nucleoprotein (HBcAg)-specific CD4+ and CD8+ T cell …

Intrahepatic, nucleocapsid antigen-specific T cells in chronic active hepatitis B.

C Ferrari, A Penna, T Giuberti, MJ Tong… - … (Baltimore, Md.: 1950 …, 1987 - journals.aai.org
Hepatitis B core antigen (HBcAg)-specific T cell lines were established from hepatic
lymphomononuclear cells derived from five patients with chronic active hepatitis B. No …

Functional modulation of hepatitis B core antigen-specific T lymphocytes by an autoreactive T cell clone.

C Ferrari, FV Chisari, E Ribera, A Penna… - Journal of immunology …, 1988 - journals.aai.org
Abstract Hepatitis B core (HBc) Ag-specific T cells present in the peripheral blood of a
patient with chronic active hepatitis B were expanded by co-cultivation for 7 days with …

Hepatitis B virus-reactive human T lymphocyte clones: antigen specificity and helper function for antibody synthesis.

E Celis, PC Kung, TW Chang - Journal of immunology (Baltimore …, 1984 - journals.aai.org
To study immunity to hepatitis B surface antigen (HBsAg) at the cellular level, lymphocytes
were obtained from the peripheral blood of hepatitis B vaccine recipients and were …

Selective sensitization of peripheral blood T lymphocytes to hepatitis B core antigen in patients with chronic active hepatitis type B.

C Ferrari, A Penna, P Sansoni, T Giuberti… - Clinical and …, 1986 - ncbi.nlm.nih.gov
The proliferative response of peripheral blood T cells to hepatitis B surface antigen (HBsAg),
pre-S antigen and hepatitis B core antigen (HBcAg) has been studied in 20 patients with …

Selective expansion of cytotoxic T lymphocytes with a CD4+ CD56+ surface phenotype and a T helper type 1 profile of cytokine secretion in the liver of patients …

V Barnaba, A Franco, M Paroli… - … (Baltimore, Md.: 1950 …, 1994 - journals.aai.org
Highly purified CD4+ T cells isolated from liver biopsies of patients with hepatitis B virus-
induced CAH had a strong cytotoxic activity and were comprised of a substantial number of …

Specificity of T lymphocyte cytotoxicity to autologous hepatocytes in chronic hepatitis B virus infection: evidence that T cells are directed against HBV core antigen …

M Mondelli, GM Vergani, A Alberti… - … (Baltimore, Md.: 1950 …, 1982 - journals.aai.org
Peripheral blood T lymphocytes from 21 patients with chronic HBV infection were incubated
with autologous hepatocytes in a microcytotoxicity assay. Cytotoxicity was significantly …

Induction of T-helper cell response to hepatitis B core antigen in chronic hepatitis B: a major factor in activation of the host immune response to the hepatitis B virus

G Marinos, F Torre, S Chokshi, M Hussain, BE Clarke… - Hepatology, 1995 - Elsevier
The T helper (Th) cell response to hepatitis B core antigen (HBcAg) was analyzed in 76
chronic hepatitis B virus (HBV) carriers with varying degrees of hepatic inflammation and …

Defect in Th1-like cells of nonresponders to hepatitis B vaccine

MG Chedid, H Deulofeut, DE Yunis… - Human immunology, 1997 - Elsevier
Peripheral blood lymphocytes from nonresponders to hepatitis B vaccine (HBsAg) failed to
undergo a proliferative response to recombinant HBsAg in vitro, whereas cells from …

Cellular immune response to hepatitis B virus antigens: an overview

C Ferrari, A Penna, A DegliAntoni, F Fiaccadori - Journal of hepatology, 1988 - Elsevier
It has been suggested that the cellular immune response to HBV antigens is responsible for
hepatocellular injury in acute and chronic hepatitis B. However, definitive immunological …