Background Epidermal growth factor receptor (EGFR) is an essential target for cancer
treatment. However, EGFR inhibitor erlotinib showed limited clinical benefit in pancreatic …

Background Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant
diseases because of its non-symptomatic tumorigenesis. We previous found heat shock …

Abstract Background Pancreatic stellate cells (PSCs) play key roles in the pancreatic tumor
microenvironment and are considered to contribute to chemoresistance. PSCs can …

Background Hypoxia plays a vital role in cancer epithelial to mesenchymal transition (EMT)
and invasion. However, it is not quite clear how hypoxia may contribute to these events …

Background Pancreatic cancer is one of the representative solid tumors, in which the
hypoxic microenvironment plays a crucial role in malignant progression. We previously …

Hypoxia promotes angiogenesis, proliferation, invasion, and metastasis of pancreatic
cancer. Essentially, all studies of the hypoxia pathway in pancreatic cancer research to date …

Background Aberrant expression of epidermal growth factor receptor (EGFR) has been
detected in pancreatic cancer; however, the mechanisms of EGFR in inducing pancreatic …

High expression of the epidermal growth factor receptor (EGFR) has been implicated in the
development of pancreatic cancer. Gefitinib is an orally active and selective EGFR‐TKI …

Background Intratumoral hypoxia and epithelial–mesenchymal transition are involved in
tumor invasion and metastasis. Aims This study investigated the molecular mechanisms that …

Background Excessive expression of EGFR is closely related to tumor formation, transfer
and deterioration, which has attracted much attention. EGFR overexpression may be …