This review explores various strategies aimed at improving the solubilization of low-solubility
drugs, including formulation design, nanoparticle technologies, prodrug strategies, and …

Solubility, a critical parameter governing the bioavailability and therapeutic efficacy of
pharmaceutical compounds, often poses a significant challenge in drug development. This …

Background: In the current pharmaceutical industry, overcoming drug insolubility is a
daunting formulation challenge. The most active drugs (with receptor affinity and specificity …

A drug's aqueous solubility is defined as the ability to dissolve in a particular solvent, and it
is currently a major hurdle in bringing new drug molecules to the market. According to some …

This manuscript offers a comprehensive overview of nanotechnology's impact on the
solubility and bioavailability of poorly soluble drugs, with a focus on BCS Class II and IV …

The low water solubility of pharmacoactive molecules limits their pharmacological potential,
but the solubility parameter cannot compromise, and so different approaches are employed …

The poor water solubility of numerous novel drug candidates presents significant
challenges, particularly in terms of oral administration. This limitation can result in various …

Highlights•Use of computational modeling in drug solubility prediction is presented.•
Computational theories related to solubility are discussed.•Applications of computational …

Resolving Solubility Problems and Providing an Overview of Excipients to Boost Oral Drug
Bioavailability Page 1 Asian Journal of Pharmaceutics • Oct-Dec 2023 • 17 (4) | 692 …

Introduction: For poorly soluble compounds, a good bioavailability is typically needed to
assess the therapeutic index and the suitability of the compound for technical development …