Islet transplantation is an emerging treatment for type-1 diabetes. Pancreas preservation has
been identified as an area for improvement since many pancreata are exposed to> 6-8 …

BACKGROUND: Islet transplantation is a promising treatment for type 1 diabetes. Due to a
shortage of suitable human pancreata, high cost, and the large dose of islets presently …

Islet transplantation is emerging as a promising treatment for patients with type 1 diabetes. It
is important to maximize viable islet yield for each organ due to scarcity of suitable human …

Expanding the available human donor pool (eg, to nonheartbeating donors) is very
important for islet transplantation and the well executed study recently published in …

BACKGROUND: The two-layer method (TLM) for pancreas preservation reportedly improves
islet yield and transplantation outcome relative to previous methods. Increased ATP …

Background. Oxygenation of the pancreas during preservation by the two-layer method
(TLM) has shown beneficial effects in islet transplantation. Here, we apply this concept …

Background: The recent unprecedented interest in islet allotransplantation has been
tempered by the observation that sustained freedom from exogenous insulin is rarely …

31P-NMR spectroscopy was utilized to investigate rat and porcine pancreatic ATP: Pi ratios
to assess the efficacy of existing protocols for cold preservation (CP) in maintaining organ …

Previous reports indicate that the two-layer method (TLM) of human pancreas preservation
is superior to University of Wisconsin solution (UW) when pancreata are preserved for …

Aims: The oxygenation of the human pancreas during cold storage was recently established
for clinical islet transplantation by introduction of the two-layer method (TLM). Nevertheless …