A germline oncogenic MITF mutation and tumor susceptibility

B Bressac-de Paillerets, F Lesueur… - European journal of cell …, 2014 - Elsevier
MITF (Microphthalmia-associated transcription factor) is a lineage specific transcription
factor that plays a critical role in melanocyte homeostasis and whose deregulation has been …

Frequent mutations in the MITF pathway in melanoma

JC Cronin, J Wunderlich, SK Loftus… - Pigment cell & …, 2009 - Wiley Online Library
Microphthalmia‐associated transcription factor (MITF) is involved in melanocyte cell
development, pigmentation and neoplasia. To determine whether MITF is somatically …

Melanocytes and the Microphthalmia Transcription Factor Network

E Steingrímsson, NG Copeland, NA Jenkins - Annu. Rev. Genet., 2004 - annualreviews.org
▪ Abstract The first mouse microphthalmia transcription factor (Mitf) mutation was discovered
over 60 years ago, and since then over 24 spontaneous and induced mutations have been …

MITF: master regulator of melanocyte development and melanoma oncogene

C Levy, M Khaled, DE Fisher - Trends in molecular medicine, 2006 - cell.com
Microphthalmia-associated transcription factor (MITF) acts as a master regulator of
melanocyte development, function and survival by modulating various differentiation and …

Microphthalmia-associated transcription factor: a differentiation marker in uveal melanoma

MC Gelmi, RM Verdijk, LE Houtzagers… - International Journal of …, 2023 - mdpi.com
Microphthalmia-associated transcription factor (MITF) is an important regulator of
melanogenesis and melanocyte development. In cutaneous melanoma, MITF loss has been …

Microphthalmia‐associated transcription factor expression levels in melanoma cells contribute to cell invasion and proliferation

J Vachtenheim, L Ondrušová - Experimental dermatology, 2015 - Wiley Online Library
Microphthalmia‐associated transcription factor (MITF) is a nodal point in melanoma
transcriptional network that regulates dozens of genes with critical functions in cell …

A dominant negative mutant of microphthalmia transcription factor (MITF) lacking two transactivation domains suppresses transcription mediated by wild type MITF and …

J Vachtenheim, B Drdová - Pigment cell research, 2004 - Wiley Online Library
Microphthalmia transcription factor (MITF) positively regulates transcription of differentiation‐
related genes in several cell lineages, including melanocytes. Recent data also indicate a …

Malignant melanoma and the role of the paradoxal protein Microphthalmia transcription factor

L Denat, L Larue - Bulletin du cancer, 2007 - jle.com
Mitf protein is a transcription factor involved all along the life of pigmented cells. This protein
is located in the center of multiple signaling pathways which control differentiation …

MITF in melanoma: mechanisms behind its expression and activity

ML Hartman, M Czyz - Cellular and Molecular Life Sciences, 2015 - Springer
MITF (microphthalmia-associated transcription factor) represents a melanocytic lineage-
specific transcription factor whose role is profoundly extended in malignant melanoma. Over …

[PDF][PDF] The many roles of MITF in melanoma

J Vachtenheim - Single Cell Biol, 2017 - m.23michael.com
Microphthalmia-associated transcription factor (MITF) plays pivotal role in the maintenance
of the melanocyte lineage, differentiation of normal and malignant melanocytes and the …