Free radical-induced macromolecular damage has been studied extensively as a
mechanism of oxidative stress, but large-scale intervention trials with free radical …

A well-regulated redox state is essential for normal physiological function and cellular
metabolism. In most eukaryotic cells, protein cysteine thiols are most sensitive to fluctuations …

Cells respond to many stimuli by transmitting signals through redox-regulated pathways. It is
generally accepted that in many instances signal transduction is via reversible oxidation of …

Free radical-derived reactive oxygen species (ROS) are constantly generated in most living
tissue and can potentially damage DNA, proteins and lipids.“Oxidative stress” occurs if ROS …

Exposure of cells to sublethal oxidative stress results in the modulation of various signaling
pathways. Oxidants can activate and inactivate transcription factors, membrane channels …

Oxidative stress is often defined as an imbalance of pro-oxidants and antioxidants, which
can be quantified in humans as the redox state of plasma GSH/GSSG. Plasma GSH redox in …

The sulfur biochemistry of the thiol group endows cysteines with a number of highly
specialized and unique features that enable them to serve a variety of different functions in …

Publisher Summary The thiol redox status of intracellular and extracellular compartments is
critical in the determination of protein structure, regulation of enzyme activity, and control of …

Living cells maintain a delicate balance between oxidizing and reducing species, and many
disorders such as rheumatoid arthritis and Alzheimer's disease have been associated with a …

▪ Abstract Many proteins present on cell surfaces and located in extracellular fluids contain
cysteine and methionine residues that are subject to oxidation. These proteins, which …