[HTML][HTML] Utilizing pathophysiological concepts of ischemia-reperfusion injury to design renoprotective strategies and therapeutic interventions for normothermic ex vivo …

B Ogurlu, TL Hamelink, IM Van Tricht… - American Journal of …, 2024 - Elsevier
Normothermic machine perfusion (NMP) has emerged as a promising tool for the
preservation, viability assessment, and repair of deceased-donor kidneys prior to …

HYPOTHERMIC PERFUSION OF THE KIDNEY: FROM RESEARCH TO CLINICAL PRACTICE

G Radi, G Fallani, G Germinario… - European Journal …, 2023 - eujtransplantation.com
Kidney transplantation is the treatment of choice for patients with end stage renal disease
(ESRD). Donor availability is lower than demand, therefore suboptimal grafts retrieved from …

Ex-vivo Kidney Machine Perfusion: Therapeutic Potential

R Zulpaite, P Miknevicius, B Leber, K Strupas… - Frontiers in …, 2021 - frontiersin.org
Kidney transplantation remains the gold standard treatment for patients suffering from end-
stage kidney disease. To meet the constantly growing organ demands grafts donated after …

Brief normothermic machine perfusion rejuvenates discarded human kidneys

AM Hameed, DB Lu, E Patrick, BO Xu, M Hu… - Transplantation …, 2019 - journals.lww.com
Background. Normothermic machine perfusion (NMP) may allow resuscitation and improved
assessment of kidneys before transplantation. Using discarded human kidneys, we …

Normothermic Ex Vivo Kidney Perfusion Following Static Cold Storage—Brief, Intermediate, or Prolonged Perfusion for Optimal Renal Graft Reconditioning?

JM Kaths, J Echeverri, I Linares, JY Cen… - American Journal of …, 2017 - Wiley Online Library
Normothermic ex vivo kidney perfusion (NEVKP) demonstrated superior results compared to
hypothermic storage in donation after circulatory death (DCD) kidney transplantation. It is …

The effects of arterial pressure during normothermic kidney perfusion

M Patel, S Hosgood, ML Nicholson - Journal of Surgical Research, 2014 - Elsevier
Background Ex vivo normothermic perfusion (EVNP) can reverse some of the detrimental
effects of ischemic injury. However, in kidneys with warm and cold ischemic injury the …

Subnormothermic machine perfusion for preservation of porcine kidneys in a donation after circulatory death model

DP Hoyer, A Gallinat, S Swoboda… - Transplant …, 2014 - Wiley Online Library
Machine perfusion for preservation led to compelling success for the outcome of renal
transplantation. Further refinements of methods to decrease preservation injury remain an …

The future of organ perfusion and re‐conditioning

A Weissenbacher, G Vrakas, D Nasralla… - Transplant …, 2019 - Wiley Online Library
Organ preservation and re‐conditioning using machine perfusion technologies continue to
generate promising results in terms of viability assessment, organ utilization and improved …

Adding Medicine During Machine Perfusion: A Breakthrough in Kidney Transplantation?

B Jespersen - Transplantation, 2016 - journals.lww.com
Imperial College London, published an interesting article on improved renal graft perfusion
by the addition of thrombalexin to the perfusion fluid during hypothermic machine perfusion …

Prolonged (≥ 24 hours) normothermic (≥ 32° C) ex vivo organ perfusion: lessons from the literature

LN Tchouta, F Alghanem, A Rojas-Pena… - Transplantation, 2021 - journals.lww.com
For 2 centuries, researchers have studied ex vivo perfusion intending to preserve the
physiologic function of isolated organs. If it were indeed possible to maintain ex vivo organ …