Background: Tumor-derived cell lines are widely used to study the mechanisms involved in
thyroid carcinogenesis but recent studies have reported redundancy among thyroid cancer …

Cell lines are crucial to elucidate mechanisms of tumorigenesis and serve as tools for
cancer treatment screenings. Therefore, careful validation of whether these models have …

Objective To investigate the molecular underpinnings of thyroid cancer, preclinical cell line
models are crucial; however,∼ 40% of these have been proven to be either duplicates of …

The overall prognosis of thyroid cancer is excellent, but some patients have grossly invasive
disease and distant metastases with limited responses to systemic therapies. Thus, relevant …

Thyroid cancer is the most common endocrine malignancy. Although the majority of thyroid
cancers are well differentiated and have a favorable prognosis, a minor proportion are …

Objective: Our aim was to characterize the molecular and genotypic profile of eight thyroid
carcinoma–derived cell lines—TPC1, FB2, B-CPAP, K1, XTC-1, C643, 8505C, and Hth74 …

Carcinomas of the thyroid are common. They are generally slowly growing and run an
indolent course. Consequently, the vast majority of cases are curable, if appropriate …

Since the 1980s, cancer cells have been considered to be generated from well-differentiated
benign cells by transformation caused by accumulating damage in their genomes. However …

Thyroid cancers are the most common endocrine malignancy. Radiation exposure, family
history of thyroid cancer and some inherited conditions are the most important predisposing …

A novel hypothesis of thyroid carcinogenesis, the “fetal cell carcinogenesis” hypothesis, in
which cancer cells are derived from the remnants of three types of fetal thyroid cells, instead …