The involvement of the nitric oxide (NO)/cyclic GMP pathway in the molecular mechanisms
of antinociceptive drugs like morphine has been previously shown by our group …

In view of the scarce information about the analgesic mechanism of κ-opioid receptor
agonists, the objective of the present study was to determine whether nitric oxide (NO) is …

The aim of this study was to examine if the peripheral antinociception of α-bisabolol involves
the participation of nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) synthesis …

The aim of this study was to examine if the peripheral antinociceptive effects of the opioid
agonist/antagonist nalbuphine and buprenorphine involve the sequential participation of …

There is evidence that local peripheral administration of morphine produces antinociception
through the activation of the nitric oxide (NO)-cyclic GMP-K+ channels pathway. Therefore …

Pamabrom is a diuretic that is effective in treating premenstrual syndrome and primary
dysmenorrhea. The aim of this study was to examine the effect of metformin and modulators …

In order to investigate to the contribution of K+ channels on the peripheral antinociception
induced by diclofenac, we evaluated the effect of several K+ channel blockers, using the rat …

1 We evaluated the effects of the iev administration of different K+ channel blockers
(gliquidone, 4‐aminopyridine and tetraethylammonium) and an opener of K+ channels …

Studies have demonstrated that the L-arginine/NO/cGMP pathway and the potassium and
calcium channels are involved in the mechanisms underlying opioid receptor activation. As …

BACKGROUND: The involvement of the l-arginine/nitric oxide (NO)/cyclic guanosine
monophosphate (cGMP) pathway in antinociception has been implicated as a molecular …