Using the rat paw pressure test, in which increased sensitivity is induced by intraplantar
injection of prostaglandin E2, we studied the action of several K+ channel blockers in order …

1 The pharmacological profile of GR94839, a κ‐opioid agonist with limited access to the
central nervous system, has been investigated. Its antinociceptive activity has been …

The antinociceptive effect of nitrous oxide (N2O) is dependent on nitric oxide (NO); however,
the next step in the pathway activated by NO is undetermined. The present study was …

NSAIDs represent some of the most widely prescribed drugs for relief of short-term fever,
pain and inflammation. The participation of the opioid system in the peripheral is poorly …

The development of tolerance, and the possibility of cross-tolerance, to the κ-opioid receptor-
mediated antinociceptive effects of U69, 593 and bremazocine was studied in mice. U69 …

TRK-820, a new type of 4, 5-epoxymorphinan derivative, was investigated in vivo for
antinociceptive activities and its selectivity on various opioid receptors in mice. Trk-820 …

Naloxone has been used to antagonize opioid effects for many years, even though at low
doses it can exert antinociceptive effects. This 'paradoxical'analgesia has been detected …

The role of peripheral potassium channels on the antinociceptive effect of Crotalus durissus
terrificus venom, a mixed δ-and κ-opioid receptor agonist, was investigated in hyperalgesia …

Background and Purpose Oxycodone and morphine are μ‐opioid receptor agonists
prescribed to control moderate‐to‐severe pain. Previous studies suggested that these …

In addition to the central and spinal sites of action of morphine both our laboratory and
others have demonstrated that opiates can also cause analgesia through a peripheral …