Background: Complicated urinary tract infections (cUTI) are universal reasons for
hospitalization, and highly likely to develop into sepsis or septic shock. Carbapenem …

This systematic review and meta-analysis evaluated the clinical efficacy and safety of
carbapenems for the treatment of complicated urinary tract infections (cUTIs), with the …

Introduction Complicated urinary tract infections (cUTIs) are associated with poor prognosis.
The widespread infection of multidrug-resistant Gram-negative uropathogens such as …

Objective This meta-analysis aimed at assessing the clinical efficacy and safety of novel
antibiotics for complicated urinary tract infections (cUTIs). Methods Three electronic …

Highlights•Frequent use of carbapenem increases selection of carbapenem resistant
Enterobacterales•To alleviate this, we reviewed alternative strategies against complicated …

The global threat of the spread of carbapenem resistance in Enterobacteriaceae has led to
the search for new antibacterials. Intravenous meropenem/vaborbactam (Vabomere™) is …

Background. The global emergence of carbapenem-resistant Enterobacteriaceae highlights
the urgent need to reduce carbapenem dependence. The phase 3 RECAPTURE program …

Introduction Complicated urinary tract infections (cUTIs) entail diverse clinical conditions that
could be managed differently and not necessarily with premature empiric therapy. Since …

As antimicrobial resistance continues to grow, one of the biggest threats includes the
members of the Enterobacterales order presenting with carbapenem resistance (CRE) …

Noninferiority trial design and analyses are commonly used to establish the effectiveness of
a new antimicrobial drug for treatment of serious infections such as complicated urinary tract …