Importance of the field: Since ethinyl estradiol is a potent activator of hepatic enzymes, the
use of natural estradiol (E2) has been studied; but, until recently, bleeding control has …

Estradiol valerate and dienogest have been combined to create a novel four-phasic oral
contraceptive pill effective for both pregnancy prevention and treatment of heavy menstrual …

Objective To summarise all clinical data on the contraceptive efficacy and bleeding profile
associated with an oestradiol valerate (E2V) and dienogest (DNG)[E2V/DNG] combined oral …

Abnormal uterine bleeding (AUB) is associated with significant direct medical costs and
impacts both society and the quality of life for individual women. Heavy menstrual bleeding …

Most combination oral contraceptives contain ethinyl estradiol and a progestin. A new and
novel oral contraceptive formulation combines estradiol valerate (E2V) with dienogest …

BACKGROUND: Estradiol valerate/dienogest (E2V/DNG) is a combined oral contraceptive
(COC) with 2 new hormonal entities and a unique 4-phasic dosing regimen indicated for …

Background: This study investigated the efficacy and safety of a combined oral contraceptive
(COC) containing estradiol valerate/dienogest (E2V/DNG). Methods: This was a multicenter …

The new estradiol valerate and dienogest oral contraceptive pill recently received US Food
and Drug Administration (FDA) approval to treat heavy menstrual bleeding in women without …

Objective: To review the pharmacology, pharmacokinetics, efficacy, and safety of the new
oral contraceptive estradiol valerate/dienogest. Data Sources: Searches of PubMed (1966 …

Abstract▴ Estradiol valerate/dienogest is an oral contraceptive for women that combines the
natural estrogen estradiol with the 19-nortestosterone derivative dienogest in a four-phasic …