[HTML][HTML] Glycosylation of cancer extracellular vesicles: capture strategies, functional roles and potential clinical applications

ÁM Martins, CC Ramos, D Freitas, CA Reis - Cells, 2021 - mdpi.com
Glycans are major constituents of extracellular vesicles (EVs). Alterations in the
glycosylation pathway are a common feature of cancer cells, which gives rise to de novo or …

Glycoconjugates from extracellular vesicles: Structures, functions and emerging potential as cancer biomarkers

J Costa - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2017 - Elsevier
Extracellular vesicles (EVs) are released by virtually all cells, carry cellular molecules to the
extracellular environment, and may interact with other cells. They are found in body fluids …

Different isolation approaches lead to diverse glycosylated extracellular vesicle populations

D Freitas, M Balmaña, J Poças, D Campos… - Journal of …, 2019 - Taylor & Francis
Extracellular vesicles (EVs) are a heterogeneous group of small secreted particles involved
in intercellular communication and mediating a broad spectrum of biological functions. EVs …

Altered biodistribution of deglycosylated extracellular vesicles through enhanced cellular uptake

N Nishida-Aoki, N Tominaga, N Kosaka… - Journal of extracellular …, 2020 - Taylor & Francis
Extracellular vesicles (EVs) from cancer are delivered both proximal and distal organs. EVs
are highly glycosylated at the surface where EVs interact with cells and therefore has an …

Glycosylation of extracellular vesicles: current knowledge, tools and clinical perspectives

C Williams, F Royo, O Aizpurua-Olaizola… - Journal of …, 2018 - Taylor & Francis
It is now acknowledged that extracellular vesicles (EVs) are important effectors in a vast
number of biological processes through intercellular transfer of biomolecules. Increasing …

Extracellular vesicles in cancer therapy

SE Wang - Seminars in cancer biology, 2022 - Elsevier
Extracellular vesicles (EVs), including a variety of membrane-enclosed nanosized particles
carrying cell-derived cargo, mediate a major type of intercellular communication in …

[HTML][HTML] Glycosylation in extracellular vesicles: Isolation, characterization, composition, analysis and clinical applications

V Vrablova, N Kosutova, A Blsakova, A Bertokova… - Biotechnology …, 2023 - Elsevier
This review provides a comprehensive overview of our understanding of the role that
glycans play in the formation, loading and release of extracellular vesicles (EVs). The …

[HTML][HTML] Extracellular vesicles from ovarian carcinoma cells display specific glycosignatures

J Gomes, P Gomes-Alves, SB Carvalho, C Peixoto… - Biomolecules, 2015 - mdpi.com
Cells release vesicles to the extracellular environment with characteristic nucleic acid,
protein, lipid, and glycan composition. Here we have isolated and characterized …

[HTML][HTML] Intercellular vesicular transfer by exosomes, microparticles and oncosomes-implications for cancer biology and treatments

R Jaiswal, LM Sedger - Frontiers in oncology, 2019 - frontiersin.org
Intercellular communication is a normal feature of most physiological interactions between
cells in healthy organisms. While cells communicate directly through intimate physiology …

Extracellular vesicles as natural therapeutic agents and innate drug delivery systems for cancer treatment: Recent advances, current obstacles, and challenges for …

M Pirisinu, TC Pham, DX Zhang, TN Hong… - Seminars in Cancer …, 2022 - Elsevier
As cancer poses a significant threat to the well-being of humans on a global scale, many
researchers have embarked on the search for effective anticancer therapeutic agents. In …