Minocycline as a promising therapeutic strategy for chronic pain
YQ Zhou, DQ Liu, SP Chen, J Sun, XM Wang… - Pharmacological …, 2018 - Elsevier
Chronic pain remains to be a clinical challenge due to insufficient therapeutic strategies.
Minocycline is a member of the tetracycline class of antibiotics, which has been used in …
Minocycline is a member of the tetracycline class of antibiotics, which has been used in …
Minocycline for controlling neuropathic pain: a systematic narrative review of studies in humans
Objective Minocycline is known to reduce microglial activation, suggesting that it may reduce
neuropathic pain. We reviewed studies in humans that evaluated the effectiveness of …
neuropathic pain. We reviewed studies in humans that evaluated the effectiveness of …
Tetracyclines and pain
LFS Bastos, ACP de Oliveira, LR Watkins… - Naunyn-Schmiedeberg's …, 2012 - Springer
Tetracyclines are natural or semi-synthetic bacteriostatic agents which have been used
since late 1940s against a wide range of gram-positive and gram-negative bacteria and …
since late 1940s against a wide range of gram-positive and gram-negative bacteria and …
Minocycline prevents the development of neuropathic pain, but not acute pain: possible anti-inflammatory and antioxidant mechanisms
SSV Padi, SK Kulkarni - European journal of pharmacology, 2008 - Elsevier
Glia, particularly astrocytes and microglia, are known to play an important role in central
sensitization and are strongly implicated in the exaggerated pain states. In the present study …
sensitization and are strongly implicated in the exaggerated pain states. In the present study …
Minocycline does not decrease intensity of neuropathic pain intensity, but does improve its affective dimension
M Sumitani, H Ueda, J Hozumi, R Inoue… - Journal of pain & …, 2016 - Taylor & Francis
Recent understanding of the neuron–glia communication shed light on an important role of
microglia to develop neuropathic pain The analgesic effect of minocycline on neuropathic …
microglia to develop neuropathic pain The analgesic effect of minocycline on neuropathic …
Effect of minocycline on lumbar radicular neuropathic pain: a randomized, placebo-controlled, double-blind clinical trial with amitriptyline as a comparator
P Vanelderen, J Van Zundert, T Kozicz, M Puylaert… - …, 2015 - pubs.asahq.org
Background: Less than 50% of patients experience sufficient pain relief with current drug
therapy for neuropathic pain. Minocycline shows promising results in rodent models of …
therapy for neuropathic pain. Minocycline shows promising results in rodent models of …
[HTML][HTML] Minocycline attenuates bone cancer pain in rats by inhibiting NF-κB in spinal astrocytes
Z Song, B Xiong, X Guan, F Cao, A Manyande… - Acta Pharmacologica …, 2016 - nature.com
Aim: To investigate the mechanisms underlying the anti-nociceptive effect of minocycline on
bone cancer pain (BCP) in rats. Methods: A rat model of BCP was established by inoculating …
bone cancer pain (BCP) in rats. Methods: A rat model of BCP was established by inoculating …
Analgesic effect of minocycline in rat model of inflammation-induced visceral pain
P Kannampalli, S Pochiraju, M Bruckert… - European journal of …, 2014 - Elsevier
The present study investigates the analgesic effect of minocycline, a semi-synthetic
tetracycline antibiotic, in a rat model of inflammation-induced visceral pain. Inflammation …
tetracycline antibiotic, in a rat model of inflammation-induced visceral pain. Inflammation …
[HTML][HTML] Minocycline effects on IL-6 concentration in macrophage and microglial cells in a rat model of neuropathic pain
Background: Evidence indicates that neuropathic pain pathogenesis is not confined to
changes in the activity of neuronal systems but involves interactions between neurons …
changes in the activity of neuronal systems but involves interactions between neurons …
A minocycline derivative reduces nerve injury-induced allodynia, LPS-induced prostaglandin E2 microglial production and signaling via toll-like receptors 2 and 4
LFS Bastos, AM Godin, Y Zhang, S Jarussophon… - Neuroscience …, 2013 - Elsevier
Many studies have shown that minocycline, an antibacterial tetracycline, suppresses
experimental pain. While minocycline's positive effects on pain resolution suggest that …
experimental pain. While minocycline's positive effects on pain resolution suggest that …