Pharmacokinetics and metabolism of oral midazolam in preterm infants
SN De Wildt, GL Kearns, WCJ Hop… - British journal of …, 2002 - Wiley Online Library
Aims To characterize the pharmacokinetics and metabolism of oral midazolam in 15 preterm
infants. Methods After an oral dose (0.1 mg kg− 1), blood was drawn up to 24 h after …
infants. Methods After an oral dose (0.1 mg kg− 1), blood was drawn up to 24 h after …
Pharmacokinetics and metabolism of intravenous midazolam in preterm infants
SN De Wildt, GL Kearns, WCJ Hop… - Clinical …, 2001 - Wiley Online Library
Background Midazolam, a benzodiazepine, is finding expanded use in neonatal intensive
care units. We studied the pharmacokinetics and metabolism of midazolam after a single …
care units. We studied the pharmacokinetics and metabolism of midazolam after a single …
Population pharmacokinetics of midazolam in neonates
P Burtin, E Jacqz‐Aigrain, P Girard… - Clinical …, 1994 - Wiley Online Library
Objective To describe the pharmacokinetics of midazolam, a water‐soluble benzodiazepine
with a short half‐life, in critically ill neonates. Hypothesis Midazolam clearance is reduced in …
with a short half‐life, in critically ill neonates. Hypothesis Midazolam clearance is reduced in …
Ontogeny of midazolam glucuronidation in preterm infants
Purpose In preterm infants, the biotransformation of midazolam (M) to 1-OH-midazolam
(OHM) by cytochrome P450 3A4 (CYP3A4) is developmentally immature, but it is currently …
(OHM) by cytochrome P450 3A4 (CYP3A4) is developmentally immature, but it is currently …
Measurement by HPLC of Midazolam and its Major Metabolite 1‐Hydroxymidazolam in Plasma of Very Premature Neonates
TC Lee, B Charles - Biomedical Chromatography, 1996 - Wiley Online Library
A simple, selective high‐performance liquid chromatographic method with ultraviolet
detection at 220nm is described for quantitation of midazolam and its primary metabolite 1 …
detection at 220nm is described for quantitation of midazolam and its primary metabolite 1 …
Pharmacodynamics of intravenous and oral midazolam in preterm infants
SN de Wildt, GL Kearns, SD Sie, WCJ Hop… - Clinical drug …, 2003 - Springer
Objective The aim of this study was to evaluate the pharmacodynamics and safety of
midazolam after intravenous infusion or oral administration in preterm infants. Methods] …
midazolam after intravenous infusion or oral administration in preterm infants. Methods] …
Clinical pharmacology of midazolam in neonates and children: effect of disease—a review
GM Pacifici - International journal of pediatrics, 2014 - Wiley Online Library
Midazolam is a benzodiazepine with rapid onset of action and short duration of effect. In
healthy neonates the half‐life (t1/2) and the clearance (Cl) are 3.3‐fold longer and 3.7‐fold …
healthy neonates the half‐life (t1/2) and the clearance (Cl) are 3.3‐fold longer and 3.7‐fold …
Pharmacokinetics of midazolam in critically ill neonates
E Jacqz-Aigrain, C Wood, I Robieux - European journal of clinical …, 1990 - Springer
Midazolam is a water soluble benzodiazepine, with a short elimination half-life in adults and
children. An IV bolus of midazolam 0.2 mg· kg− 1 was administered to 10 critically ill …
children. An IV bolus of midazolam 0.2 mg· kg− 1 was administered to 10 critically ill …
Pharmacokinetics of midazolam during continuous infusion in critically ill neonates
E Jacqz-Aigrain, P Daoud, P Burtin, S Maherzi… - European journal of …, 1992 - Springer
Midazolam is a water soluble benzodiazepine, with a short elimination half-life in adults and
children. An IV bolus (0.2 mg· kg− 1) immediately followed by continuous infusion of 0.06 …
children. An IV bolus (0.2 mg· kg− 1) immediately followed by continuous infusion of 0.06 …
The pharmacokinetics of midazolam in paediatric patients
K Payne, FJ Mattheyse, D Liebenberg… - European journal of …, 1989 - Springer
A serum concentration profile study on midazolam in children was done. Fifty six children
aged 3–10 years took part. The routes investigated were intravenous, intramuscular, rectal …
aged 3–10 years took part. The routes investigated were intravenous, intramuscular, rectal …
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