Streptococcus pyogenes is a globally prominent human-specific pathogen responsible for
an enormous burden of human illnesses, including> 600 million pharyngeal and> 100 …

Humans commonly carry pathogenic bacteria asymptomatically, but despite decades of
study, the underlying molecular contributors remain poorly understood. Here, we show that a …

The important human pathogen Streptococcus pyogenes (group A Streptococcus [GAS])
produces a hyaluronic acid (HA) capsule that plays critical roles in immune evasion …

Group A streptococci (GAS) cause various diseases, from uncomplicated noninvasive, to
severe invasive infections. Capsular hyaluronic acid (HA) is known to resist phagocytosis …

To investigate the role of putative virulence factors of Streptococcus pyogenes (group A
streptococcus; GAS) in causing disease, we introduced specific mutations in GAS strain …

The pro-inflammatory cytokine IL-6 regulates antimicrobial responses that are broadly
crucial in the defense against infection. Our prior work shows that IL-6 promotes the killing of …

Group A Streptococcus (GAS) commonly infects human skin and occasionally causes
severe and life-threatening invasive diseases. The hyaluronan (HA) capsule of GAS has …

Capsular polysaccharide production by group A Streptococcus (GAS) is controlled by
transcription of the has operon that encodes the enzymes uniquely required for synthesis of …

Direct interaction between pathogens and host cells often is a prerequisite for colonization,
infection and dissemination. Regulated production of capsular polysaccharide (CPS), which …

Some pathogenic bacteria form thick capsules that both block immune responses through
inhibition of complement deposition and phagocytosis and stimulate a weak response …