Microphthalmia transcription factor (Mitf), a melanocytic nuclear protein critical for the
embryonic development and postnatal viability of melanocytes, is a master lineage regulator …

The basic-helix–loop–helix-leucine zipper (bHLHZip) protein MITF (microphthalmia-
associated transcription factor) is a master regulator of melanocyte development. Mutations …

Purpose: Understanding tumor heterogeneity is an important challenge in current cancer
research. Transcription and epigenetic profiling of cultured melanoma cells have defined at …

The microphthalmia transcription factor MITF plays important roles in several cell lineages
including retinal and neural crest‐derived pigment cells. Previous reports have shown that …

The diagnosis of malignant melanoma is sometimes challenging. Immunohistochemistry for
specific markers of melanocytic differentiation such as HMB-45 and Melan-A can be very …

MITF, a gene that is mutated in familial melanoma and Waardenburg syndrome, encodes
multiple isoforms expressed from alternative promoters that share common coding exons but …

Microphthalmia transcription factor (Mitf) is a nuclear protein involved in the development of
melanocytes and the regulation of melanin synthesis. Recent studies have suggested that …

The controls that enable melanoblasts and melanoma cells to proliferate are likely to be
related, but so far no key regulator of cell cycle progression specific to the melanocyte …

A rare germline variant in the microphthalmia‐associated transcription factor (MITF) gene,
E318K, has been reported as associated with melanoma. We confirmed its independent …

The Microphthalmia-associated transcription factor (MITF) is an important regulator of cell-
type specific functions in melanocytic cells. MITF is essential for the survival of pigmented …