The tumor suppressor p53 has been implicated in apoptosis induction and is mutated in
human T-ALL CCRF-CEM cells. To investigate possible consequences of wild-type p53 …

M1 myeloid leukemic cells overexpressing wild-type p53 undergo apoptosis. This apoptosis
can be suppressed by some cytokines, protease inhibitors, and antioxidants. We now show …

The p53 protein accumulates rapidly through post-transcriptional mechanisms following
cellular exposure to DNA damaging agents and is also activated as a transcription factor …

Loss of normal p53 function was found frequently to interfere with response of cancer cells to
conventional anticancer therapies. Since more than half of all human cancers possess p53 …

The doxorubicin (ADR)-selected human breast cancer cell line (MCF-7/ADR-RES) has been
a useful model for a multidrug-resistant subline in cancer research. However, a recent letter …

The p53 tumor suppressor protein can induce both apoptosis and cell cycle arrest.
Moreover, we and others have shown previously that p53 is a potent mediator of …

The p53 tumor suppressor gene product can induce apoptotic cell death through an
unknown mechanism. Here we demonstrate that a temperature-sensitive p53 induces …

Human lymphoblastoid cells were transfected with expression vectors containing p53 cDNA
mutated at either codon 135 or 246. The cells were subjected to cisplatin treatment or γ …

Many recent studies have implicated p53 in the cellular response to injury and induction of
cell death by apoptosis. In a rat embryonal fibroblast cell line transformed with c-Ha-ras and …

Abstract p53‐mediated transcription activity is essential for cell cycle arrest, but its
importance for apoptosis remains controversial. To address this question, we employed …