Normothermic ex vivo kidney perfusion for the preservation of kidney grafts prior to transplantation

JM Kaths, VN Spetzler, N Goldaracena… - JoVE (Journal of …, 2015 - jove.com
Kidney transplantation has become a well-established treatment option for patients with end-
stage renal failure. The persisting organ shortage remains a serious problem. Therefore, the …

Normothermic ex vivo kidney perfusion for human kidney transplantation: first North American results

LI Mazilescu, P Urbanellis, SJ Kim, T Goto… - …, 2022 - journals.lww.com
Background. Normothermic ex vivo kidney perfusion (NEVKP) has shown promising results
for preservation, assessment, and reconditioning of kidney allografts in preclinical studies …

Dissemination of a novel organ perfusion technique: ex vivo normothermic perfusion of deceased donor kidneys

P Chandak, BL Phillips, R Uwechue… - Artificial …, 2019 - Wiley Online Library
Ex vivo normothermic perfusion (EVNP) technology is a promising means of organ
preservation, assessment, and preconditioning prior to kidney transplantation, which has …

Kidney perfusion: some like it hot others prefer to keep it cool

I Jochmans, ML Nicholson… - Current Opinion in Organ …, 2017 - journals.lww.com
A great deal of research is still needed to optimize and logistically place hypothermic and
normothermic perfusion technologies. In the future, we may progress toward organ-tailored …

Eight-hour continuous normothermic ex vivo kidney perfusion is a safe preservation technique for kidney transplantation: a new opportunity for the storage …

JM Kaths, J Echeverri, N Goldaracena, KS Louis… - …, 2016 - journals.lww.com
Background Hypothermic kidney storage causes preservation injury and is poorly tolerated
by renal grafts. We investigated whether static cold storage (SCS) can be safely replaced …

Normothermic ex vivo kidney perfusion reduces warm ischemic injury of porcine kidney grafts retrieved after circulatory death

M Hamar, P Urbanellis, MJ Kaths, D Kollmann… - …, 2018 - journals.lww.com
Background Cold storage is poorly tolerated by kidney grafts retrieved after donation after
circulatory death. It has been determined that normothermic ex vivo kidney perfusion …

Prolonged normothermic ex vivo kidney perfusion is superior to cold nonoxygenated and oxygenated machine perfusion for the preservation of DCD porcine kidney …

LI Mazilescu, P Urbanellis, MJ Kaths… - Transplantation …, 2021 - journals.lww.com
Background. The increased usage of marginal grafts has triggered interest in perfused
kidney preservation to minimize graft injury. We used a donation after circulatory death …

Normothermic Ex Vivo Kidney Perfusion Following Static Cold Storage—Brief, Intermediate, or Prolonged Perfusion for Optimal Renal Graft Reconditioning?

JM Kaths, J Echeverri, I Linares, JY Cen… - American Journal of …, 2017 - Wiley Online Library
Normothermic ex vivo kidney perfusion (NEVKP) demonstrated superior results compared to
hypothermic storage in donation after circulatory death (DCD) kidney transplantation. It is …

Ex vivo machine perfusion for renal graft preservation

JM Kaths, A Paul, LA Robinson, M Selzner - Transplantation Reviews, 2018 - Elsevier
Kidney transplantation is the treatment of choice for end-stage renal disease. Despite its
superiority over dialysis, the persisting organ shortage remains a major drawback …

Normothermic machine perfusion of the kidney: better conditioning and repair?

SA Hosgood, E van Heurn… - Transplant …, 2015 - Wiley Online Library
Kidney transplantation is limited by hypothermic preservation techniques. Prolonged periods
of cold ischaemia increase the risk of early graft dysfunction and reduce long‐term survival …