De novo DNA methylation: a germ cell perspective
SA Smallwood, G Kelsey - Trends in Genetics, 2012 - cell.com
DNA methylation is a fundamentally important epigenetic modification of the mammalian
genome that has widespread influences on gene expression. During germ-cell specification …
genome that has widespread influences on gene expression. During germ-cell specification …
DNA methylation dynamics during the mammalian life cycle
JA Hackett, MA Surani - … of the Royal Society B: Biological …, 2013 - royalsocietypublishing.org
DNA methylation is dynamically remodelled during the mammalian life cycle through distinct
phases of reprogramming and de novo methylation. These events enable the acquisition of …
phases of reprogramming and de novo methylation. These events enable the acquisition of …
DNA methylation dynamics during epigenetic reprogramming in the germline and preimplantation embryos
DM Messerschmidt, BB Knowles… - Genes & …, 2014 - genesdev.cshlp.org
Methylation of DNA is an essential epigenetic control mechanism in mammals. During
embryonic development, cells are directed toward their future lineages, and DNA …
embryonic development, cells are directed toward their future lineages, and DNA …
DNA methylation reprogramming during mammalian development
Y Zeng, T Chen - Genes, 2019 - mdpi.com
DNA methylation (5-methylcytosine, 5mC) is a major form of DNA modification in the
mammalian genome that plays critical roles in chromatin structure and gene expression. In …
mammalian genome that plays critical roles in chromatin structure and gene expression. In …
[HTML][HTML] Conceptual links between DNA methylation reprogramming in the early embryo and primordial germ cells
DNA methylation is a carrier of important regulatory information that undergoes global
reprogramming in the mammalian germ line, including pre-implantation embryos and …
reprogramming in the mammalian germ line, including pre-implantation embryos and …
The diverse roles of DNA methylation in mammalian development and disease
MVC Greenberg, D Bourc'his - Nature reviews Molecular cell biology, 2019 - nature.com
DNA methylation is of paramount importance for mammalian embryonic development. DNA
methylation has numerous functions: it is implicated in the repression of transposons and …
methylation has numerous functions: it is implicated in the repression of transposons and …
Imprinting and epigenetic changes in the early embryo
JR Weaver, M Susiarjo, MS Bartolomei - Mammalian Genome, 2009 - Springer
Imprinted genes are epigenetically regulated so that only one allele is expressed in a parent-
of-origin-dependent manner. Although they represent a small subset of the mammalian …
of-origin-dependent manner. Although they represent a small subset of the mammalian …
DNA methylation in early development
TM Geiman, K Muegge - Molecular Reproduction and …, 2010 - Wiley Online Library
Abstract Development from separate parental germ cells through fertilization and
proceeding to a fully functioning adult animal occurs through an intricate program of …
proceeding to a fully functioning adult animal occurs through an intricate program of …
Epigenetic resetting in the human germ line entails histone modification remodeling
Epigenetic resetting in the mammalian germ line entails acute DNA demethylation, which
lays the foundation for gametogenesis, totipotency, and embryonic development. We …
lays the foundation for gametogenesis, totipotency, and embryonic development. We …
Emerging concept in DNA methylation: role of transcription factors in shaping DNA methylation patterns
DNA methylation in mammals is a key epigenetic modification essential to normal genome
regulation and development. DNA methylation patterns are established during early …
regulation and development. DNA methylation patterns are established during early …