Background Atherosclerosis is a common and serious vascular disease predisposing
individuals to myocardial infarction and stroke. Intravascular plaques, the pathologic lesions …

Objective—To investigate the effects of pioglitazone (PIO), a peroxisome proliferator–
activated receptor γ agonist, on plaque matrix metalloproteinase (MMP) and macrophage …

Background α V β 3-integrin is expressed by activated endothelial cells and macrophages in
atherosclerotic plaques and may represent a valuable marker of high-risk plaques. We …

With advances in imaging technology and our understanding of the role of inflammation in
atherosclerosis, the macrophage appears to be an excellent target for imaging the …

Background Coronary atherosclerosis and its thrombotic complications are the major cause
of mortality and morbidity throughout the industrialized world. Thrombosis on disrupted …

Background—Macrophages participate centrally in atherosclerosis, and macrophage
markers (eg, CD68, MAC-3) correlate well with lesion severity and therapeutic modulation …

Cardiovascular diseases (CVD) are the leading cause of mortality worldwide. Despite major
advances in the treatment of CVD, a high proportion of CVD victims die suddenly while …

Imaging of atheromatous plaques has traditionally centered on assessing the degree of
luminal stenosis. More recently it has become clear that the vulnerable atherosclerotic …

Macrophages are key inflammatory mediators in many pathological conditions, including
cardiovascular disease (CVD) and cancer, the leading causes of morbidity and mortality …

Apoptosis of macrophages and smooth muscle cells is linked to atherosclerotic plaque
destabilization. The apoptotic cascade leads to exposure of phosphatidylethanolamine (PE) …