HIV vaccine design and evaluation require a better understanding of protective immune
responses. HIV-specific CD8+ T-cell responses have been characterized extensively using …

Current guidelines recommend initiation of antiretroviral therapy (ART) when a HIV patient
has< 200 CD4 T cells/μL. This is supported by many studies. For example, the probability of …

Background: It still remains controversial which kind of relationships exist between HIV-1-
specific CD8 T-cell responses and HIV RNA load or CD4 count over the course of the …

Objective: Vaccine-induced CD8+ T-cell responses in primates have been associated with a
reduced simian immunodeficiency virus plasma viral load and enhanced T-cell responses …

The causal relationship between HIV-specific CD4+ T-cell responses and viral control and
the effect of these responses on the natural history of HIV infection is unclear. In a detailed …

Methods: T-cell responses were investigated using flow cytometry and novel subtype A
variant inclusive peptide (VIP) sets designed for this evaluation. CD4 T-cell responses …

Relationships among four serologic activation markers and T cell subsets were measured in
HIV-seropositive former blood donors (N= 64) and seronegative controls (N= 61). Significant …

Background: To control HIV globally, a comprehensive understanding of host immunity to
HIV in different human populations is needed. Relatively, little is known on the quantity and …

Objectives: To determine whether increased sequence variation occurs in regions of
endogenous HIV-1 targeted by HIV-1-specific CD4+ T cells. The presence of increased …

In a clinical trial involving asymptomatic, HIV-seropositive subjects treated with either the
HIV-1 immunogen (an inactivated, gp120-depleted HIV-1 virus in incomplete Freund's …