Purpose: Prostate cancer is typically a disease of elderly men and, therefore, it has not been
well characterized in those affected at a young age. With the advent of serum prostate …

Objective: The aim of this study was to describe the clinical characteristics of early onset
prostate cancer, with special reference to family history as a possible prognostic factor …

Prostate cancer is considered a disease of older men (aged> 65 years), but today over 10%
of new diagnoses in the USA occur in young men aged≤ 55 years. Early-onset prostate …

Background: Familial prostate cancer risk estimates are inflated by clinically insignificant low-
risk cancer, diagnosed after prostate-specific antigen testing. We provide age-specific …

Background In a large number of studies a positive family history is documented as one of
the main risk factors for the development of prostate cancer. In a US population an …

Prostate cancer is the most common non-cutaneous malignancy in men. It is generally
considered a cancer of the elderly, and the median age of presentation is 68 years. However …

Objectives To compare traditional prognostic characteristics of familial vs sporadic prostate
cancers and to investigate potential detection biases arising from differences in the use of …

Genetic factors may be used not only to assess risk of prostate cancer development but also
to evaluate prostate cancer outcomes including clinical prognosis, treatment methods, and …

Previous studies have indicated that hereditary prostate cancer is common among men with
early onset prostate cancer. The aim of this study was to investigate the incidence of …

Current epidemiologic and genetic data suggest the hypothetical paradigm that prostate
cancer occurs in three forms: sporadic, familial, and hereditary (Figure 1). Sporadic cases …