Signal sequence deletion and fusion to tetanus toxoid epitope augment antitumor immune responses to a human carcinoembryonic antigen (CEA) plasmid DNA …
LH Lund, K Andersson, B Zuber, A Karlsson… - Cancer gene …, 2003 - nature.com
Abstract Carcinoembryonic antigen (CEA, CEACAM5) is expressed on several human
carcinomas including colon cancer. CEA contains signal peptides that target the protein …
carcinomas including colon cancer. CEA contains signal peptides that target the protein …
Efficient induction of T‐cell responses to carcinoembryonic antigen by a heterologous prime‐boost regimen using DNA and adenovirus vectors carrying a codon …
C Mennuni, F Calvaruso, A Facciabene… - … journal of cancer, 2005 - Wiley Online Library
The immunogenic properties of plasmid DNA and recombinant adenovirus (Ad) encoding
the carcinoembryonic antigen (CEA) were examined in mice by measuring both the …
the carcinoembryonic antigen (CEA) were examined in mice by measuring both the …
Recombinant AAV-CEA tumor vaccine in combination with an immune adjuvant breaks tolerance and provides protective immunity
JA Hensel, V Khattar, S Ponnazhagan - Molecular Therapy-Oncolytics, 2019 - cell.com
Carcinoembryonic antigen (CEA) is a human glycoprotein involved in cellular adhesion and
expressed during human fetal development. Although expression of CEA largely ceases …
expressed during human fetal development. Although expression of CEA largely ceases …
Characterization of genetically modified T-cell receptors that recognize the CEA: 691-699 peptide in the context of HLA-A2. 1 on human colorectal cancer cells
MR Parkhurst, J Joo, JP Riley, Z Yu, Y Li… - Clinical Cancer …, 2009 - AACR
Purpose: Carcinoembryonic antigen (CEA) is a tumor-associated protein expressed on a
variety of adenocarcinomas. To develop an immunotherapy for patients with cancers that …
variety of adenocarcinomas. To develop an immunotherapy for patients with cancers that …
DNA and adenoviral vectors encoding carcinoembryonic antigen fused to immunoenhancing sequences augment antigen-specific immune response and confer …
A panel of vectors was constructed to encode carcinoembryonic antigen (CEA) fused at its C-
terminal end to various polypeptides, so as to compare their immunogenicity by plasmid …
terminal end to various polypeptides, so as to compare their immunogenicity by plasmid …
Expression of transgenic carcinoembryonic antigen (CEA) in tumor‐prone mice: An animal model for CEA‐directed tumor immunotherapy
JA Thompson, AM Eades‐Perner… - … journal of cancer, 1997 - Wiley Online Library
Carcinoembryonic antigen (CEA) is a tumor marker for the most common forms of
adenocarcinomas. We have previously described C57BL/6 mice transgenic for the complete …
adenocarcinomas. We have previously described C57BL/6 mice transgenic for the complete …
Induction of mucosal and systemic immune responses against human carcinoembryonic antigen by an oral vaccine
Y Huang, R Fayad, A Smock, AM Ullrich, L Qiao - Cancer research, 2005 - AACR
Carcinoembryonic antigen (CEA) is a tumor-associated antigen targeted for the
development of colorectal tumor vaccines. In this study, we developed papillomavirus …
development of colorectal tumor vaccines. In this study, we developed papillomavirus …
Novel mouse model for carcinoembryonic antigen-based therapy
CHF Chan, CP Stanners - Molecular therapy, 2004 - cell.com
Many novel cancer therapies, including immunotherapy and gene therapy, are specifically
targeted to tumor-associated molecules, among which carcinoembryonic antigen (CEA) …
targeted to tumor-associated molecules, among which carcinoembryonic antigen (CEA) …
Protective immunity against human carcinoembryonic antigen (CEA) induced by an oral DNA vaccine in CEA-transgenic mice
R Xiang, S Silletti, HN Lode, CS Dolman… - Clinical cancer …, 2001 - AACR
Peripheral T-cell tolerance toward human carcinoembryonic self-antigen (CEA) was broken
in CEA-transgenic C57BL/6J mice by an oral CEA-based DNA vaccine. This vaccine …
in CEA-transgenic C57BL/6J mice by an oral CEA-based DNA vaccine. This vaccine …
Immunogenicity of the carcinoembryonic antigen derived peptide 694 in HLA-A2 healthy donors and colorectal carcinoma patients
PMS Alves, S Viatte, T Fagerberg, O Michielin… - Cancer Immunology …, 2007 - Springer
Carcinoembryonic antigen (CEACAM5) is commonly overexpressed in human colon cancer.
Several antigenic peptides recognized by cytolytic CD8+ T-cells have been identified and …
Several antigenic peptides recognized by cytolytic CD8+ T-cells have been identified and …